sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. sirolimus must be used within a narrow therapeutic window. due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. t...

tricho-dento-osseous syndrome is a rare autosomal dominant disorder. immunosuppressive drugs, though critical to the treatment, have undesirable effects on patient's healing process. this is a case report of a 10-year-old female, suffering from tricho-dento-osseous syndrome who was under treatment with penicillamine. as the dental treatment was sought too late, both central and lateral incisors...

The first successful kidney transplantation between monozygotic identical twins did not require any immunosuppressive drugs. Clinical application of azathioprine and glucocorticosteroids allowed the transfer of organs between genetically disparate donors and recipients. Transplantation is now the standard of care, a life-saving procedure for patients with failed organs. Progress in our understa...