sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. sirolimus must be used within a narrow therapeutic window. due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. t...

background:chronic idiopathic thrombocytopenic purpura (itp) is an autoimmune disorder characterized by a low platelet count due to reduced production and higher destruction of the platelets. therapy is aimed at increasing the patient’s platelet count to safe levels and includes a wide variety of treatments, which has a large impact on the patient’s quality of life. health related quality of li...

background: there is a controversy about the relation between anti-hepatitis b (anti-hbs) antibody level and obesity. we designed this study to compare the vaccine efficacy in obese/overweight and non-obese cases. methods: in this cross-sectional study, 242 obese/overweight and 85 non-obese individuals were participated. cases were selected from a referral clinic for obesity and a referral hepa...

Summary The immunosuppressive agent has changed the clinical course of MS. Mostly,this agent, like cyclophosphamide cyclosporine A., and X-Ray of the lymphoid organ, has a lot of side effects. It should only be used in the most severe from of MS among immunosuppressive agents, Azathioprin has been used most frequently in spite of the fact that it is not very effective compared with other immun...

conclusions based on its effects, carnosol might be considered a source of drug, showing effective immunosuppression properties. further studies should be performed on carnosol to develop an effective immunosuppressive drug or coadjuvant for the treatment of disorders caused by an exaggerated or unwanted immune response. results results showed that three high doses of carnosol (0.8, 2.4 and 4 m...

Sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. Sirolimus must be used within a narrow therapeutic window. Due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. T...