The development of subunit vaccines has become very attractive in recent years due to their superior safety profiles as compared to traditional vaccines based on live attenuated or whole inactivated pathogens, and there is an unmet medical need for improved vaccines and vaccines against pathogens for which no effective vaccines exist. The subunit vaccine technology exploits pathogen subunits as...

Immunomodulators, immunostimulants, and immunotherapies are important tools used by veterinary practitioners and researchers to control and direct the immune system of small animals. This article is an overview and summary of some of the most common immunomodulatory agents used in companion animals emphasizing steroidal and nonsteroidal agents, T-cell inhibitors, cytotoxic drugs, immunostimulat...

Dendritic cells (DC) acquire antigens in peripheral tissues, transport them to lymph nodes and present peptides to T cells. DC are particularly good activators of resting T cells. Murine Langerhans' cells (LC) are efficient at endocytosing and processing antigens but are very weak immunostimulators. In culture LC lose the ability to process antigen and become potent immunostimulators. Other per...

background: mushrooms have been valued as high tasty nutritional and nutraceutical food throughout the world. at present 270 species of mushrooms are known to have various nutritional and therapeutic properties. polysaccharides are the primary content of mushrooms that are used for their pharmaceutical properties as immunostimulators. objectives: here, mushrooms were screened for useful polysac...

We have recently demonstrated that synthetic CpG oligonucleotides (ODNs), which function as potent immunostimulators, bind to the multi-lectin receptor DEC-205, resulting in their internalization. DEC-205-deficient mice exhibit impaired dendritic-cell and B-cell maturation, impaired cytokine responses and suboptimal cytotoxic T-cell responses. As murine and human DEC-205 are highly conserved, C...

Synthetic unmethylated cytosine-guanine (CpG) oligodeoxynucleotides are immunostimulatory motifs that have shown promise as vaccines or adjuvants for diseases such as cancers and infectious diseases. In the present work, novel immuno-nanoflowers (NFs), self-assembled from long DNA integrated with tandem CpG through rolling circle replication, were developed for efficient CpG delivery and protec...

The immunomodulatory medicinal plants in pharmacognosy are relatively recent. In a number of disease situations, the immune response is impaired. Thus, either activating or inhibiting can be valuable treatment for maintaining disease-free state. Immunomodulators used chemotherapy. Even while system iscapable immunity and combating infections, germs viruses impair it.If our operating properly, w...

The effect of combining chemotherapy and immunostimulation, induced by a chemical, against a murine lymphoid leukemia was investigated. When tetramisole or levamisole were used following one administration of 1,3-bis(2-chloroethyl)-l-nitrosourea, a significantly higher percentage of long-term surviviors occurred in contrast to the groups of animals treated with drug or immunostimulant alone. Th...

Neonates and infants are more vulnerable to infections and show reduced responses to vaccination. Consequently, repeated immunizations are required to induce protection and early life vaccines against major pathogens such as influenza are yet unavailable. Formulating antigens with potent adjuvants, including immunostimulators and delivery systems, is a demonstrated approach to enhance vaccine e...