6-methyl-2-phenyl-7h-oxazolo [3,2-b] [1,2,4] triazine (1) undersent ting transformation on treatment with ammonia and primary amines to afford the corresponding imidazol [1,2-b][1,2,4] triazine (2). treatment of (1) with hydrazine hydrate gave the corresponding 3-aryl-4h-1,2,4- triazino [4,3-b][1,2,4] triazin-8 (1h)-one (3).

An effective and highly regio- and diastereoselective one-pot method for the synthesis of new polynuclear dispiroheterocyclic systems with five stereogenic centers (dispiro[imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-6,3'-pyrrolidine-2',3''-indoles]) comprising pyrrolidinyloxindole and imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine moieties has been developed. The method relies on a 1,3-dipolar ...

Reaction of 1-aryl-2-hydrazono-imidazolidines with ethyl oxamate furnished novel derivatives of imidazo [2,1-c][1,2,4] triazine.

In the tricyclic nucleoside 7-( -d-ribofuranosyl)-7H-imidazo[1,2-c]pyrazolo[4,3-e][1,2,3]triazine, C11H12N6O4, the conformation of the N-glycosyl bond is intermediate between anti and high anti [ = ÿ103.5 (3) ]. The ribofuranose moiety adopts a 3T 2 sugar pucker (S-type sugar) and the conformation at the exocyclic CÐC bond is ap (gauche±trans). Molecules of the title compound form a three-dimen...

A series of novel fused heterocyclic compounds bearing benzo[4,5]imidazo[1,2-d][1,2,4]triazine 4a-4w were designed and conveniently synthesized via the intermediates 2-(halogenated alkyl)-1H-benzo[d]imidazoles 2a, 2b, and 2-((1-(substituted phenyl)hydrazinyl)alkyl)-1H-benzo[d]imidazoles 3a-3g. The structures of all target compounds were characterized by FT-IR, ¹H NMR, 13C NMR, and EI-MS, of whi...

6-Methyl-2-phenyl-7H-Oxazolo [3,2-b] [1,2,4] triazine (1) undersent ting transformation on treatment with ammonia and primary amines to afford the corresponding imidazol [1,2-b][1,2,4] triazine (2). Treatment of (1) with hydrazine hydrate gave the corresponding 3-aryl-4H-1,2,4- triazino [4,3-b][1,2,4] triazin-8 (1H)-one (3).

A number of 3-amino-1, 2, 4-triazin-5 (2H)- ones(1) were synthesized and condensed with a-haloketones to give 2,6-disubstituted imidazo [1, 2-b] [1, 2, 4]-triazin-3 (4H)-ones (2). These compounds were reacted further with a - haloketones to yield N-alkylated products (3).

a number of 3-amino-1, 2, 4-triazin-5 (2h)- ones(1) were synthesized and condensed with a-haloketones to give 2,6-disubstituted imidazo [1, 2-b] [1, 2, 4]-triazin-3 (4h)-ones (2). these compounds were reacted further with a - haloketones to yield n-alkylated products (3).

Since the time that benzimidazole was recognized to be a structural analogue of adenine, and its antimicrobial action was found to be antagonized competitively by this purine (l), several other antimetabolites of the purines have been described. Thus, carbon atom 8 of the ring system has been replaced by a nitrogen atom to yield analogues of adenine, guanine, and hypoxanthine (2). Likewise, the...