Background: Vascular endothelial growth factor A (VEGFA) plays a key role in angiogenesis during human placenta formation and its abnormal expressions have been reported in placental tissues of women with recurrent miscarriage (RM). Objective: The aim of this study was to evaluate the correlation of polymorphism of VEGF1154 G/A gene in RM and In Vitro Fertiliz...

The success of reproduction, although gradually increasing over the years, many couples also had been left frustrated following repeated failed attempts. Implantation of the embryo, can only take place in a receptive uterus and inadequate uterine receptivity is responsible for approximately two-thirds of implantation failures. Endometrial receptivity can be reduced by morphological and/or molec...

BACKGROUND We aimed to study T-helper 1 (Th1) and Th2 intracellular cytokine expression in peripheral blood lymphocytes of women with recurrent spontaneous abortions (RSA) or infertility with multiple implantation failures after IVF cycles. METHODS Twenty-six women with three or more RSA and 23 with two or more IVF failures (14 with no history of spontaneous abortion (SAB) and nine with more ...

BACKGROUND This study was designed to evaluate the incidence of uterine pathologies in infertile women with a history of two implantation failures after in vitro fertilization (IVF) and estimate the effect of hysteroscopic correction on achieving a pregnancy in these patients. MATERIALS AND METHODS The retrospective study population included 238 infertile women attended the outpatient inferti...

background: despite numerous developments in the field of assisted reproduction, the implantation rate remains low. among the various reasons of implantation failure, endometrial regularity has an important role. hysteroscopy is an accurate method for evaluating the endometrial characteristics, with the ability to treat uterine pathology. objective: the aim of the present study was to evaluate ...

OBJECTIVE To verify whether microinjection into retrieved oocytes of motile spermatozoa with morphologically normal nuclei, strictly defined by high power light microscopy (x >6000), improves the IVF/intracytoplasmic sperm injection (ICSI) pregnancy rate in couples with repeated ICSI failures. DESIGN Comparative prospective study testing routine IVF/ICSI outcome parameters against those of mo...

background: gnrh agonist administration in the luteal phase has been suggested to beneficially affect the outcome of intracytoplasmic sperm injection (icsi) and embryo transfer (et) cycles. this blind randomized controlled study evaluates the effect of gnrh (gonadotropine releasing hormone) agonist administration on icsi outcome in gnrh antagonist ovarian stimulation protocol in women with 2 or...

PGD (preimplantation genetic diagnosis) of aneuploidy for chromosomes X, Y, 13, 18 and 21 was carried out on 196 embryos from 36 infertile patients classified with a poor prognosis due to (i) maternal age, (ii) repeated in-vitro fertilization (IVF) failures and (iii) mosaic karyotype. The percentage of abnormal embryos was comparable in the three groups of patients: maternal age 63%, repeated I...