Ion-sensitive field effect transistor (ISFET) sensor is a hot topic these years, playing the combined roles of signal recognizer and converter for (bio)chemical analytes. In this review article, basic concept, origination, history ISFET are presented. addition, common fabrication processes, most-used working principle (potentiometric, amperometric, impedancemetric), techniques gate functionalit...

A program for the simulation of the response of an ISFET with an oxynitride gateinsulator will be introduced, which is based on the site-binding model and is designed for an ISFET working in constant charge mode. With this program, principal properties of ISFET operation can be calculated, such as pH sensitivity dependent on surface charge density and surface composition. In addition, an ISFET ...

Ion-sensitive, field-effect transistors (ISFET) have been useful biosensors in many applications. However, the signal-to-noise ratio of the ISFET is limited by its intrinsic, low-frequency noise. This paper presents an ISFET capable of utilizing lateral-bipolar conduction to reduce low-frequency noise. With a particular layout design, the conduction efficiency is further enhanced. Moreover, the...

We report the design of a silicon chip dedicated to the in-situ monitoring of soil nitrogen cycle in wheat crop. Our study shows that ion-sensitive field effect transistor (ISFET) microsensors are suitable for quick on-site or long-term analysis of nutrients measured directly in soil as opposed to soil extracts analysis. Our pH-ISFET recorded soil pH for six months with results in good accordan...

Ion-sensitive field-effect transistors (ISFETs), although they have attracted considerable attention as effective immunosensors, have still not been adopted for practical applications owing to several problems: (1) the poor sensitivity caused by the short Debye screening length in media with high ion concentration, (2) time-consuming preconditioning processes for achieving the highly-diluted me...

Recently, thin-film transistor based-ISFETs with the dual-gate (DG) structures have been proposed, in order to beat the Nernst response of the standard ISFET, utilizing diverse organic or inorganic materials. The immutable Nernst response can be dramatically transformed to an ultra-sensing margin, with the capacitive-coupling arisen from the DG structure. In order to advance this platform, we h...

Body fluids are often used as specimens for medical diagnosis. With the advent of advanced analytical techniques in biotechnology, the diagnostic potential of saliva has been the focus of many studies. We recently reported the presence of excess salivary sugars, in patients with Alzheimer's disease (AD). In the present study, we developed a highly sensitive, cell-based biosensor to detect treha...

Ž . Ž . An ion-selective field effect transistor ISFET was applied as a potentiometric detector in liquid chromatography LC for the Ž determination of organic acids. The ISFET was prepared by coating the gate insulator of the encapsulated transistor with a poly vinyl . Ž . chloride PVC matrix membrane containing methyltridodecylammoniumchloride, which enables the detection of organic anions. Th...

An ion-sensitive field-effect transistor (ISFET) biosensor is thought to be the center of the next era of health diagnosis. However, questions are raised about its functions and reliability in liquid samples. Consequently, real-life clinical applications are few in number. In this study, we report a strategy to minimize the sensing signal drift error during bioanalyte detection in an ISFET bios...

Over the past decades, considerable development and improvement can be observed in area of ion-sensitive field-effect transistor (ISFET) for biosensing applications. The mature semiconductor industry provides a solid foundation commercialization ISFET-based sensors extensive research has been conducted to improve performance ISFET, with special focus on materials, device structures, readout top...