Background: Atrial Fibrillation (AF) is the most common cardiac arrhythmia and an independent risk factor for stroke among the elderly. A role for inflammation in the atrial remodeling as well as development and recurrence of AF is known. Objective: To compare IL-17A between patients with different types of AF and healthy individuals. Methods: IL-17A was measured in sera of 112 patients and 107...

background: atrial fibrillation (af) is the most common cardiac arrhythmia and an independent risk factor for stroke among the elderly. a role for inflammation in the atrial remodeling as well as development and recurrence of af is known. objective: to compare il-17a between patients with different types of af and healthy individuals. methods: il-17a was measured in sera of 112 patients and 107...

Background and Aims: Recent evidence suggests that T helper (Th) 17 cells are involved in the emergence of asthma. Th17 cells have a key role in inducing inflammation in asthmatic airways thus Interleukin (IL)-17A, the main cytokine of Th17, contributes to airways inflammation. Materials and Methods: We evaluated the level of IL-17A and total immunoglobulin E (IgE) in sera of 100 asthmatic p...

context the aim of this review was to address the recent data regarding the role of il-17a in the pathogenesis of depression and its complications, such as cancer. evidence acquisition this review article summarizes the recent data on the role of il-17a in depression, using the pubmed and google scholar databases. results it has been documented that depression may alter the immune response via ...

sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. it is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. the balance between th1, th17 and regulatory t(treg) cells controls t-cell proliferation and activation.the th17/treg ratio in the peripheral blood and bronchoalveolar lavage fluid...

il-1β and il-17a are two cytokines with strong proinflammatory activities and are now known to be involved in a number of chronic inflammatory disorders. high-mobility group box 1 (hmgb1) is a nuclear protein regulating the expression of these proinflammatory cytokines. the nlrp3 inflammasome promotes the maturation of the il-1β and its activation has been shown as a critical mechanism in the p...

bakground: multiple sclerosis (ms) is a cd4+ t cell-mediated autoimmune disease affecting the central nervous system (cns). it was previously believed that th1 cells were pathogenic t cells in experimental autoimmune encephalomyelitis (eae). however, the functional role of th1 cells in eae has been reconsidered upon the discovery of il-17- producing t cells which are consider as dominant effect...

Background: Pre-eclampsia (PE) is one of the most important and life-threatening pregnancy disorders that affect at least 3-5% of all pregnancies. Imbalance in helper T cell functions may play a role in predisposing to PE or severity of the disease. Elevated frequencies of Th17 cells in the peripheral blood of PE patients have been reported. Several single nucleotide polymorphisms (SNP) within ...