نتایج جستجو برای: IGFBP1

تعداد نتایج: 229  

2010
Moira S Lewitt Agneta Hilding Kerstin Brismar Suad Efendic Claes-Göran Östenson Kerstin Hall

OBJECTIVE Low levels of IGF-binding protein 1 (IGFBP1) are associated with metabolic syndrome and predict diabetes development in men. The aim of this study was to determine the levels of IGFBP1 in women who later develop diabetes, in relation to abdominal obesity, and to compare these levels with those of men. METHODS IGFBP1 levels were determined at baseline and after 8 years in a case-cont...

2017
Wei Zheng Yayu Lai Peng Jin Wenzhu Gu Qi Zhou Xiaojing Wu

Aims. Local IGFBP1 level was reported to affect the development of coronary artery plaque. This study investigated the association of circulating IGFBP1 level with the severity of coronary artery lesions in patients with unstable angina. Materials and Methods. In 112 consecutive patients with clinically diagnosed unstable angina, admitted from July 2014 to July 2015, we studied the correlations...

2016
Fang Zheng Jingjing Wu Xiong Li Qing Tang LiJun Yang Xiaobing Yang WanYin Wu Swei Sunny Hann

The aim of this study is to investigate the actions of Chinese herbal medicine, called "Fuzheng Kang-Ai" (FZKA for short) decoction, against non-small cell lung cancer (NSCLC) and its mechanisms in vitro and in vivo. We showed that the effect of FZKA decoction significantly inhibited growth of A549 and PC9 cells. Furthermore, FZKA increased phosphorylation of AMP-activated protein kinase alpha ...

2016
Li Jun Yang Qing Tang Jingjing Wu Yuqing Chen Fang Zheng Zhenhui Dai Swei Sunny Hann

BACKGROUND Ursolic acid (UA), a natural pentacyclic triterpenoid, exerts anti-tumor effects in various cancer types including hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying this remain largely unknown. METHODS Cell viability and cell cycle were examined by MTT and Flow cytometry assays. Western blot analysis was performed to measure the phosphorylation and protei...

Journal: :Biochimica et biophysica acta 2016
Qing Tang JingJing Wu Fang Zheng Swei Sunny Hann YuQing Chen

BACKGROUND Emodin has anti-neoplastic activities on multiple tumors. However, the molecular mechanisms underlying this effect still remain to be fully understood. METHODS Cell viability and cell cycle distribution were measured using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays and flow cytometry, respectively. Cell invasion and migration were examined by transw...

Journal: :Molecular medicine reports 2013
Peipei Zhang Sofya Suidasari Tomomi Hasegawa Noriyuki Yanaka Norihisa Kato

Increasing evidence suggests that dietary vitamin B6 is linked to the prevention of cancer and cardiovascular disease. However, the molecular mechanisms involved in this process are not yet understood. Preliminary results in the current study indicated, following DNA microarray analysis and quantitative PCR, that insulin‑like growth factor‑binding protein 1 (IGFBP1) mRNA is upregulated in HT29 ...

Journal: :American journal of physiology. Endocrinology and metabolism 2016
L Shi D Banerjee A Dobierzewska S Sathishkumar A A Karakashian N V Giltiay M N Nikolova-Karakashian

The level of insulin-like growth factor-binding protein 1 (IGFBP1), a liver-produced serum protein that regulates insulin-like growth factor-I bioactivity, glucose homeostasis, and tissue regeneration, increases during inflammation. This manuscript describes a novel pathway for the regulation of hepatic IGFBP1 mRNA and protein levels by interleukin (IL)-1β. Experiments with the luciferase repor...

2016
Jing Lu Ka-Cheuk Liu Nadja Schulz Christos Karampelias Jérémie Charbord Agneta Hilding Linn Rautio Philippe Bertolino Claes-Göran Östenson Kerstin Brismar Olov Andersson

There is great interest in therapeutically harnessing endogenous regenerative mechanisms to increase the number of b cells in people with diabetes. By performing whole-genome expression profiling of zebrafish islets, we identified 11 secreted proteins that are upregulated during b-cell regeneration. We then tested the proteins’ ability to potentiate b-cell regeneration in zebrafish at supraphys...

2012
Adil Rajwani Vivienne Ezzat Jessica Smith Nadira Y. Yuldasheva Edward R. Duncan Matthew Gage Richard M. Cubbon Matthew B. Kahn Helen Imrie Afroze Abbas Hema Viswambharan Amir Aziz Piruthivi Sukumar Antonio Vidal-Puig Jaswinder K. Sethi Shouhong Xuan Ajay M. Shah Peter J. Grant Karen E. Porter Mark T. Kearney Stephen B. Wheatcroft

Low concentrations of insulin-like growth factor (IGF) binding protein-1 (IGFBP1) are associated with insulin resistance, diabetes, and cardiovascular disease. We investigated whether increasing IGFBP1 levels can prevent the development of these disorders. Metabolic and vascular phenotype were examined in response to human IGFBP1 overexpression in mice with diet-induced obesity, mice heterozygo...

2016
Jing Lu Ka-Cheuk Liu Nadja Schulz Christos Karampelias Jérémie Charbord Agneta Hilding Linn Rautio Philippe Bertolino Claes-Göran Östenson Kerstin Brismar Olov Andersson

There is great interest in therapeutically harnessing endogenous regenerative mechanisms to increase the number of β cells in people with diabetes. By performing whole-genome expression profiling of zebrafish islets, we identified 11 secreted proteins that are upregulated during β-cell regeneration. We then tested the proteins' ability to potentiate β-cell regeneration in zebrafish at supraphys...

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