نتایج جستجو برای: ID50

تعداد نتایج: 265  

Journal: :Risk analysis : an official publication of the Society for Risk Analysis 2013
Amie Adkin Neil Donaldson Louise Kelly

In this article the development and parameterization of a quantitative assessment is described that estimates the amount of TSE infectivity that is present in a whole animal carcass (bovine spongiform encephalopathy [BSE] for cattle and classical/atypical scrapie for sheep and lambs) and the amounts that subsequently fall to the floor during processing at facilities that handle specified risk m...

Journal: :The Tohoku journal of experimental medicine 1984
M Baba S Shigeta E De Clercq

Inhibition of varicella-zoster virus (VZV) replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) has been examined in vitro under various experimental conditions. The 50% inhibitory dose (ID50) of BVDU for VZV replication in human embryonal fibroblast (HEF) cultures was 0.016 micrograms/ml, if the assay was based on the reduction of visible foci. If the assay was based on the reduction of ...

Journal: :Journal of dental research 1991
C T Hanks S E Strawn J C Wataha R G Craig

The objectives of this study were to determine the cytotoxic concentrations of 11 components of resin composites on monolayers of cultured Balb/c 3T3 fibroblasts, to study the inhibitory effects of these components on DNA synthesis, total protein content, and protein synthesis, and to determine whether effects were reversible when the components were withdrawn from the medium. These data were r...

Journal: :The Biochemical journal 1980
F Stirpe R F Legg L J Onyon P Ziska H Franz

1. The haemagglutinating and toxic lectin from Viscum album L. (mistletoe) inhibits protein synthesis in a lysate of rabbit reticulocytes, with an ID50 (concentration giving 50% inhibition) of 2.6 microgram/ml. This effect is enhanced (ID50 0.21 microgram/ml) if the lectin is reduced with 2-mercaptoethanol. 2. The lectin inhibits protein synthesis also in BL8L cells in culture. Inhibition occur...

Journal: :The Veterinary record 2005
A H Grobben P J Steele R A Somerville D M Taylor B E C Schreuder

Dietary exposure to the bovine spongiform encephalopathy (BSE) agent is the probable cause of variant Creutzfeldt-Jakob disease in people. The industrial manufacturing process for the production of gelatine and colloidal protein by the heat and pressure process was downscaled accurately and its capacity to remove or inactivate bse infectivity was investigated. Gelatine was made from bones exper...

2012
João Alves Gama Sophie S. Abby Sara Vieira-Silva Francisco Dionisio Eduardo P. C. Rocha

Many studies have been devoted to understand the mechanisms used by pathogenic bacteria to exploit human hosts. These mechanisms are very diverse in the detail, but share commonalities whose quantification should enlighten the evolution of virulence from both a molecular and an ecological perspective. We mined the literature for experimental data on infectious dose of bacterial pathogens in hum...

Journal: :Cancer research 1997
J Roboz J Jiang J F Holland J G Bekesi

ID50 and ID90 values for L-prolyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester HCl (MF13), were determined in four murine (leukemia, lymphoma, melanoma, and lung) and eight human cancer cell lines (two leukemia, prostate, kidney, colon, two melanoma, and breast). Cytotoxic activity was 2-5 times higher than that of sarcolysin [(L-3-[bis(2-chloroethyl)amino]-L-phenylalanine] ...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2007
Cláudia Serafin Viviane Nart Angela Malheiros Márcia Maria de Souza Luiz Fischer Giuliano Delle Monache Franco Della Monache Valdir Cechinel Filho

The present work describes the antinociceptive properties and chemical composition of the aerial parts of Plinia glomerata (Myrtaceae). Both of the extracts evaluated, acetonic and methanolic, showed potent antinociceptive action, when analyzed against acetic acid-induced abdominal constrictions in mice, with calculated ID50 (mg/kg, i. p.) values of 24.8 and 3.3, respectively. Through usual chr...

Journal: :Antiviral research 1999
M Kundi

All biologicals whose production involves materials of human or animal origin are at risk of viral contamination. Testing the capacity of the production processes to remove or inactivate viruses is an essential step in establishing the safety of biological products. The one-hit model which is essentially based on the assumption that the assay will show a positive reaction if and only if there i...

Journal: :The Journal of antibiotics 1987
Y Take K Oogose T Kubo Y Inouye S Nakamura Y Kitahara A Kubo

Thirteen heterocyclic quinones (5 quinoline quinones, 7 isoquinoline quinones, 1 indole quinone) were tested for their effects on avian myeloblastosis virus reverse transcriptase, growth of murine lymphoblastoma L5178Y cells, respiration of rat liver mitochondria and oxidation of NADH by Clostridium kluyveri diaphorase in comparison with those of streptonigrin, in which the quinoline quinone mo...

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