v Chapter 1. General Introduction 1 Historical Perspectives 1 Fundamental Aspects of ICP-MS 2 ICP-MS Instrumentation 3 Blank Purity in ICP-MS 4 Previous EMLC Experiments 6 Matrix Effects in ICP-MS 7 Flow Injection in ICP-MS 9 Shielded Torch in ICP-MS 10 Dissertation Objectives and Organization 11 Figures 12 References 27 Chapter 2. Electrochemically-Modulated Liquid Chromatography for Cleaning ...

Inductively coupled plasma mass spectrometry (ICP-MS) is a suitable tool for multi-element analysis at low concentration levels. Rare earth element (REE) determinations in standard reference materials and small volumes of molten ice core samples from Antarctica have been performed with an ICP-time of flight-MS (ICP-TOF-MS) system. Recovery rates for REE in e.g. SPS-SW1 amounted to approximately...

The source of signal variations that governs the analytical performance of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was investigated in this study. In order to specify the source of signal variations of LA-ICP-MS, laser-induced plasma (LIP) Fe emission, LA-ICP-MS Fe+ and LA-ICP-MS Ni+ signals were used as internal standards for the determination of trace elements ...

BACKGROUND Safety assessment of nanoparticles (NPs) requires techniques that are suitable to quantify tissue and cellular uptake of NPs. The most commonly applied techniques for this purpose are based on inductively coupled plasma mass spectrometry (ICP-MS). Here we apply and compare three different ICP-MS methods to investigate the cellular uptake of TiO2 (diameter 7 or 20 nm, respectively) an...

The introduction and development of Single Particle ICP-MS (SP-ICP-MS) has opened a new area of research which allows the rapid detection and analysis of metal-based particles in a variety of matrices and applications.1-6 The key feature of SP-ICP-MS is that it allows discrete pulses of positively charged ions to be detected and measured in a time-resolved manner using microsecond (μs) data acq...

Introduction Inductively Coupled Plasma Mass Spectrometry (ICP-MS) typically provides detection limits in the low-ppt to sub-ppt range for all but a few of over 70 elements. Unfortunately, for a handful of elements, conventional ICP-MS cannot provide the best possible detection limits. The detection limits for these elements are limited by plasma or sample matrix-based polyatomic interferences....

The use of oxygen as a reaction gas for the removal of interferences in quadrupole ICP-MS is well established. However, prior to the development of the Agilent 8800 Triple Quadrupole ICP-MS (ICP-QQQ), the use of oxygen had been limited to determination of a small number of analytes in simple, well defined matrices. This is because oxygen can react with matrix components, analytes and polyatomic...

BACKGROUND Development of theranostic concepts that include inductively coupled plasma mass spectrometry (ICP-MS) and laser ablation ICP-MS (LA-ICP-MS) imaging can be hindered by the lack of a direct comparison to more standardly used methods for in vitro and in vivo evaluation; e.g. fluorescence or nuclear medicine. In this study a bimodal (or rather, hybrid) tracer that contains both a fluore...

Although a variety of techniques are available to measure nanoparticles, single particle ICP-MS (SP-ICP-MS) has become increasingly important due to its speed and ability to measure environmentally relevant low nanoparticle concentrations, surpassing the limitations of light-based technologies.6-7 Monitoring Cerium Dioxide and Zinc Oxide Nanoparticles through Drinking Water Treatments using Sin...

The technique of coupling liquid chromatography to inductively plasma mass spectrometry (ICP-MS) is reviewed. A brief introduction to the ICP-MS instrument is given as well as methods to couple the two analytical instruments together. The various types of LC that have been used with ICP-MS detection are discussed and advantages over traditional methods of detection are highlighted, such as the ...