Endotoxaemia is a major cause of equine morbidity, and plasma from horses immunised against Escherichia coli is used in its treatment. The aim of this study was to determine the effects of hyperimmune plasma on the clinical and leukocyte responses, including production and activity of TNFα, in an in vivo endotoxin challenge model. Pre-treatment with hyperimmune equine plasma had no significant ...

Plasvacc Australia (Plasvacc) 6066 Cunningham Hwy Kalbar Queensland Australia 4309 61-7-54637600 Objectives – To develop an effective Escherichia coli (E. coli) vaccine that engenders a strong and measurable humoral response in canine plasma donors. To develop an assay to determine potency of plasma derived from vaccinated canine donors. To determine efficacy of hyperimmune plasma to E. coli in...

Objectives This is a protocol for Cochrane Review (intervention). The objectives are as follows: To assess whether convalescent plasma or hyperimmune immunoglobulin transfusion effective and safe to prevent infection with SARS?CoV?2 development of COVID?19; maintain the currency evidence, using living systematic review approach.

OBJECTIVES Acute limb ischaemia is a common and often lethal clinical event. Reperfusion of an ischaemic limb has been shown to induce a remote gut injury associated with transmigration of endotoxin into the portal and systemic circulation, which in turn has been implicated in the conversion of the sterile inflammatory response to a sepsis syndrome, after lower torso ischaemia-reperfusion injur...

Introduction: Severe acute respiratory syndrome causing coronavirus SARS-CoV-2 (coronavirus disease 2019 (COVID-19)) has recently resulted in the recent global pandemic. As convalescent plasma (CP) therapy been used with success several viral infections before, it become a treatment of choice. Medical literature is reviewed for randomized controlled studies using therapy.Areas covered: More tha...

Previous studies have demonstrated the importance of antibodies in mediating immunity to malaria, but the relative contribution of the different immunoglobulin isotypes has not been assessed. In this study, hyperimmune plasma was generated against Plasmodium yoelii and separated by protein A-Sepharose chromatography into fractions containing immunoglobulin G1 (IgG1), IgG2a, IgG2b, or IgG3 antib...

Insulin resistance and metabolic syndrome are chronic inflammatory conditions that lead to hepatic injury and non-alcoholic steatohepatitis (NASH). Bovine colostrum has therapeutic effects in a variety of chronic infections. However its effectiveness in NASH was never studied. Natural killer T (NKT) cells have been shown to be associated with some of the pathological and metabolic abnormalities...

The world is experiencing a pandemic of swine-origin influenza virus H1N1. A vaccine to prevent disease is now available, and millions have or will become ill before they can be vaccinated. The ability to use swine-origin influenza virus vaccines as a public health tool has been described as a "race against time." Oseltamivir and related drugs are being used in an effort to reduce morbidity and...