background and objective: parkinson's disease (pd) is a neurodegenerative disease with selective damage of mesencephalic dopaminergic neurons. due to the protective, anti-inflammatory, and antioxidant effect of hypericum perforatum (hp), this study was undertaken to assess dose-dependent effect of hp hydroalcoholic extract on motor imbalance following intrastriatal injection of 6-hydroxydo...

Background and Objective: Parkinson's disease (PD) is a neurodegenerative disease with selective damage of mesencephalic dopaminergic neurons. Due to the protective, anti-inflammatory, and antioxidant effect of Hypericum perforatum (HP), this study was undertaken to assess dose-dependent effect of HP hydroalcoholic extract on motor imbalance following intrastriatal injection of 6-hydroxydopamin...

background and objective: parkinson's disease (pd) is an age-related neurodegenerative disease with selective damage of dopaminergic neurons of the mesencephalon. l-dihydroxyphenylamine (l-dopa) therapy is currently the gold standard maneuver for pd. due to the protective, anti-inflammatory, and antioxidant effect of sesamin, this study was undertaken to assess dose-dependent effect of this age...

background and objective: parkinson's disease (pd) is an age-related neurodegenerative disease with selective damage of dopaminergic neurons of the mesencephalon. l-dihydroxyphenylamine (l-dopa) therapy is currently the gold standard maneuver for pd. due to the protective, anti-inflammatory, and antioxidant effect of sesamin, this study was undertaken to assess dose-dependent effect of thi...

Background and Objective: Parkinson's disease (PD) is an age-related neurodegenerative disease with selective damage of dopaminergic neurons of the mesencephalon. L-dihydroxyphenylamine (L-DOPA) therapy is currently the gold standard maneuver for PD. Due to the protective, anti-inflammatory, and antioxidant effect of sesamin, this study was undertaken to assess dose-dependent effect of this age...

Herb-drug interactions are an important safety concern and this study was conducted regarding the interaction between the natural top-selling antidepressant remedy Hypericum perforatum (Hypericaceae) and conventional drugs. This study examined the influence of acute pretreatment with different extracts of Hypericum perforatum from Serbia on pentobarbital-induced sleeping time, impairment of mot...

background and objective: parkinson’s disease (pd) is a rather common neurological disorder in elders that is due to degeneration of dopaminergic neurons within mesencephalic substantia nigra pars compacta. with regard to protective and antioxidant effect of simvastatin, this study was conducted to evaluate its neuroprotective effect in an experimental model of pd. materials and methods: in thi...

BACKGROUND Extracts of Hypericum perforatum (St. John's wort) have been traditionally recommended for a wide range of medical conditions, in particular mild-to-moderate depression. The present study was designed to investigate the effect of Hypericum perforatum treatment in a mouse model of anxiety/depressive-like behavior, induced by chronic corticosterone administration. METHODS CD1 mice we...

background and objective: parkinson's disease (pd) is a movement disorder with debilitating symptoms. available treatments for pd mainly include its symptomatic relief with no prevention of its progression. due to the iron-chelating and antioxidant effect of phytic acid (pa), this study was conducted to assess its protective effect in 6-hydroxydopamine-induced model of pd in rat. materials and ...