The formation of mature mammalian collagen fibre protein requires the incorporation in peptide linkage of, inter alia, 35 residues per cent of glycine, 12 residues per cent of proline, and 10.5 residues per cent of hydroxyproline. According to our present knowledge, in the animal kingdom hydroxyproline occurs only in the collagenous group of proteins and in elastin, which contains 1.5 residues ...

Free hydroxyproline inhibits the formation of protein-bound hydroxyproline from proline to a considerably greater extent than it does the incorporation of proline into protein of auxin-treated Avena coleoptiles. This inhibition is greater in the wall than in the cytoplasmic fraction. In the absence of auxin, free hydroxyproline exerts little or no inhibition of hydroxyproline formation. Further...

Since nearly all of the hydroxyproline of the body is found in collagen, it has been suggested (1, 2) that the urinary excretion of this imino acid may be an important index of collagen metabolism. The origin of urinary hydroxyproline, however, is not definitely established. The isotopic studies of Stetten (3) in rats indirectly suggested that most of the free and peptide hydroxyproline in the ...

Values for total 3-hydroxyproline and 4-hydroxyproline were obtained from 24-h urine specimens of 18 healthy human subjects of both sexes, whose ages ranged from the first to the sixth decade in age. Urinary 3-hydroxyproline levels, not earlier described to our knowledge, were determined by an isotope-dilution method requiring considerable purification and utilizing the amino acid analyzer for ...

The significance of urinary hydroxyproline has not been completely clarified. It appears, however, that this amino acid excretion is correlated with either synthesis or destruction of collagen. Collagen hydroxyproline is reported to be formed by the irreversible hydroxylation of peptid-linked proline and no free hydroxyproline is incorporated directly into this protein. Therefore, the changes o...

the present study was conducted to investigate the histological changes and wound healing effect of aqueous extract of elaeagnus angustifolia. after creating full-thickness skin wounds on the back of 45 male sprague-dawley rats they were randomly divided into three groups. treated group received the extract, positive control group were treated with mupirocin ointment 2% and control group did no...

Background: Osteoporosis is one of the prevalent diseases post-Menopausal women. Hence to evaluate severity osteoporosis serum calcium, ALP and urinary hydroxyproline used as bone resorption marker.Method: 30 post-menopausal women with were compared healthy pre-menopausal 25-40 years Random Blood sample collected from venipuncture centrifuged get serum. Fasting Urine was 1.2 drops 6 N HCI added...