objective(s):  although several chemical and physical methods for gene delivery have been introduced, their cytotoxicity, non-specific immune responses and the lack of biodegradability remain the main issues. in this study, hydroxyapatite nanoparticles (nps) and 1,2-dioleoyl-sn-glycero-3-phosphoethanol​amine (dope)-modified hydroxyapatite nps was coated with antisense oligonucleotide of e6 mrna...

Hydroxyapatite powder has been prepared via sol-gel procedure using calcium nitrate tetrahydrate and diammonium hydrogen phosphate as the precursors for calcium and phosphorus, respectively. XRD measurement shows that the powder contains hydroxyapatite crystals with β-TCP and calcium oxide as secondary phases. Hydroxyapatite powder of higher purity, i. e., the correct Ca/P ratio, has been obtai...

Introduction: Hydroxyapatite nanoparticles inhibit the growth of various cancer cells. The inhibitory effect of these nanoparticles on breast cancer cells of mcf7 has also been reported. However, no studies have been done on the effect of the hydroxyapatite nanoparticles on the radiation sensitivities of the MCF7 cell Line. Our goal in this study is to investigate the effect of...

We describe polymer-stabilized droplets capable of recognizing and picking up nanoparticles from substrates in experiments designed for transporting hydroxyapatite nanoparticles that represent the principal elemental composition of bone. Our experiments, which are inspired by cells that carry out materials transport in vivo, used oil-in-water droplets that traverse a nanoparticle-coated substra...

Objective: to determine the effect of nano-hydroxyapatite and different bioactive remineralizing agent in treatment loss enamel minerals. Material M nano-hydroxyapatite, Casein phospho-peptide amorphous calcium phosphate Sodium Fluoride. While artificial saliva was applied on control specimens. Surface microhardness measurements baseline were calculated, before/after demineralization digital 3D...

Hydroxyapatite Ca10(PO4)6(OH)2 nanoparticles have been successfully synthesized by the wet chemical precipitation method at 60 °C in the presence of biocompatible natural surfactant-lecithin. The composition and morphology of nanoparticles of hydroxyapatite synthesized with lecithin (nHAp-PC) was studied by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning el...

in this work we synthesized nano hydroxyapatite (hap)  by sol-gel method, then we functionalized hydroxyapatite nanoparticle by use of  3-aminopropyl trimethoxysilane (aptms) , to improve the loading and control release of sulfasalazine drug bonded to aptms. the drug release patterns from sulfasalazine loaded hap nanoparticles at ph value 8 for 6h, sulfasalazine loaded functionalized hap nanopa...

Background & Aims: Aflatoxin M1 is one of the most important toxins present in milk and the product of aflatoxin B1 metabolism in liver microsomes. The aim of this project was to study the aflatoxin M1 adsorption ability of polystyrene-hydroxyapatite nanocomposite. Methods: First, the probability of aflatoxin M1 adsorption by the nanocomposite was evaluated us...

quinazolinone derivatives are essential units in a wide range of relevant pharmacophores with a broad spectrum of abilities. due to their wide range of pharmacological and therapeutic activities including anticonvulsant, anti-inflammatory, hypolipidemic, anticancer, and anti-ulcer, the synthesis of quinazolinone moieties as a privileged class of fused heterocyclic compounds, have received much ...