The main aim of this study was preparation and evaluation of extended - release system ofthe anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general propertiessimilar to those of diazepam. Our studies focused on development of extended drug deliverysystem based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent andPolyvinylpyrrolidone (PVP k30) as binder us...

this paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

The objective of the present study was formulation and evaluation pulsatile release tablets Atenolol. A tablet system consisting cores which coated with layers swelling rupturable coatings. Cores containing Atenolol as model drug were prepared by direct compression appropriate ratios lactose microcrystalline cellulose then sequentially different an inner layer HPMC outer Ethyl Cellulose. effect...

Abstract The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on the development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and polyvinylpyrrolidone (PVP k30...

Sustained release drug delivery systems are designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, maximum utilization of the drug, increased...

The aim of the present work is to design an oral time release tablet by press coating method to achieve a distinct predetermined lag time. In this study Metoprolol tartrate was selected as the model drug. The outer shell was formulated with different weight ratios of Hydroxy propyl methyl cellulose K100M and Ethyl cellulose to achieve a release profile with pre determined lag time. The lag time...

The aim of the present study was to develop a sustained release monolithic system for the low solubile/low dose glipizide, for the treatment of type II diabetes mellitus. The matrices were prepared by dry blending of polymers hydroxy propyl methyl cellulose (HPMC) or erodible Eudragit (ammonio methacrylate copolymers) and other excipients using direct compression method and were characterized u...

In the present work, monolithic matrix transdermal systems containing Drug x were prepared using various ratios of the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit S 100 (ES) with triethyl citrate as a plasticizer. A 32 full factorial design was employed. The concentration of HPMC and ES were used as independent variables, while percentage drug release was selected as d...

The aim of this study was to formulate and evaluate the novel amoxicillin trihydrate dental gel containing different hydrophilic polymers such as hydroxy propyl methyl cellulose (HPMC), methyl cellulose (MC), sodium carboxy methyl cellulose (Sod.CMC) and hydroxy propyl cellulose (HPC) in varied concentrations (5, 6, 6 and 9 %) for the treatment of periodontal diseases. Propylene glycol was used...

In the present work, monolithic matrix transdermal systems containing tramadol HCl were prepared using various ratios of the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit S 100 (ES) with triethyl citrate as a plasticizer. A 3 full factorial design was employed. The concentration of HPMC and ES were used as independent variables, while percentage drug release was selected...