the multivariate calibration method, partial least square regression (pls) was applied for thesimultaneous spectrophotometric determination of lidocaine (lid) and hydrocortisone acetate(hca) in their mixtures. the parameters of chemometric technique were optimized and theproposed method was validated with synthetic samples and applied to analyze these drugs inpharmaceutical products with good a...

Although cortisone acetate is approved worldwide as corticosteroid substitution therapy in congenital adrenal hyperplasia (21-hydroxylase deficiency), its effectiveness is uncertain since its biologic activity depends on activation by 11β-hydroxysteroid dehydrogenase (11β-HSD). We sought to compare the effect of cortisone acetate with that of hydrocortisone. In 10 patients with congenital adren...

One of three preparations-silicone oil, hydrocortisone acetate, and hydrocortisone acetate plus saline-was injected into 22 osteoarthritic and 49 rheumatoid knees. Silicone injected into stiff, dry, grating knees which were the site of chronic arthritis did not promote better movement than did hydrocortisone alone. Hydrocortisone plus saline, however, appeared to be more effective than silicone...

The suppression of inflammation in the joint structures of patients with rheumatoid arthritis by cortisone acetate administered systemically is well known. Hydrocortisone acetate, formerly known as Compound F acetate (17-hydroxycorticosterone-21-acetate), administered orally or intramuscularly, has recently been shown to have a similar suppressive effect upon this inflammation (Ward and others,...

tions of hydrocortisone and cortisone to man have established the plasma half-life of hydrocortisone to be 2 hours and that of cortisone 1 hour (1, 2). From isotopic determinations in urine, the half-life of hydrocortisone in the body has been found to be 6 hours and that of cortisone 3.6 hours (3, 4). Thus, cortisone is not only cleared from the plasma more rapidly than hydrocortisone but it i...

Involucrin accumulation and ionophore-assisted envelope formation, markers of keratinocyte differentiation, were found to be highly dependent on culture conditions in the malignant epidermal keratinocyte line, SCC-13, derived from a human squamous cell carcinoma. In confluent cultures, approximately one-half of the cells were competent to form envelopes when grown in medium without hydrocortiso...

Intra-articular hydrocortisone therapy has been in extensive use for approximately 5 years. It has been stated that this therapy is strictly for local palliation and has no systemic effects (Hollander, 1953). Local hydrocortisone therapy is especially recommended in cases in which the systemic use of cortisone is contra-indicated on general medical grounds (Kersley, 1953). On the other hand, Yo...

Local Treatment of Bronchial Asthma with Hydrocorfisone Powder H. HERXHEIMER, M.D., L.R.C.P.&S.Ed. MONICA K. MCALLEN, M.D., M.R.C.P., and D. A. WILLIAMS, M.D., M.SC. F.R.C.P. Bronchial Asthma and Chronic Bronchitis Treated with Hydrocortisone Acetate Inhalations W. H. HELM, M.R.C.P., and F. HEYWORTH, M.B. ........................................................ 765 Inhalation of Hydrocortisone ...

Hydrocortisone succinate and hydrocortisone are chromatographed with a mobile phase consisting of sodium acetate/acetonitrile (77/23, by vol), the effluent being monitored at 254 nm. p-Hydroxybenzoate-N-propyl is used as the internal standard. Detection limits are 0.5 mg/L for hydrocortisone succinate, 0.2 mg/L for hydrocortisone. For five different concentrations the respective mean analytical...