نتایج جستجو برای: Hydrazides

تعداد نتایج: 849  

Journal: :The Biochemical journal 1963
D M PHILLIPS

In connexion with studies on the N-terminal groups of histones (Phillips, 1961), a method was needed for measuring about 0-1 ,umole of aliphatic acyl groups derived from a few milligrams of protein. Initial experiments were done in which acetylamino acids and ovalbumin were hydrolysed in sulphuric acid and an ether extract was chromatographed, by using modifications of the method of Brown & Hal...

Journal: :Organic & biomolecular chemistry 2012
Xinzhang Yu Xingwei Li Boshun Wan

Palladium-catalyzed desulfitative and denitrogenative arylation of azoles with arylsulfonyl hydrazides has been achieved. A broad scope of azoles and arylsulfonyl hydrazides has been used to produce arylated azoles in high yields.

2017
Jomana Elaridi Nour Bou Karroum Kamal Bouhadir Maamoun Fatfat Hala Gali-Muhtasib

Naphthoquinones have been reported to possess a variety of pharmacological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic and anticancer effects. We have successfully synthesized a series of novel naphthoquinone acylhydrazides. The straightforward synthesis of these molecules involves a coupling reaction between 2,3-dichloro-1,4-naphthoquinon...

Journal: :Nucleic acids research 2002
Stefan Raddatz Jochen Mueller-Ibeler Joachim Kluge Ludger Wäss Gerhard Burdinski John R Havens Tom J Onofrey Daguang Wang Markus Schweitzer

We report the synthesis of new phosphoramidite building blocks and their use for the modification of oligonucleotides with hydrazides. The reaction of these hydrazide oligonucleotides with active esters and aldehydes is demonstrated for solution conjugation and immobilization. Compared with the established amino modified oligonucleotides, hydrazides show enhanced reactivity at neutral and acidi...

Journal: :Chemical communications 2011
Francis Loiseau Christian Clavette Michaël Raymond Jean-Grégoire Roveda Alishya Burrell André M Beauchemin

A systematic investigation on the metal-free, Cope-type hydroamination reactivity of hydrazides and analogues is reported. Optimization of the hydrazide structure resulted in more facile intramolecular reactivity and enabled intermolecular reactions of alkenes, thus providing a direct approach to polysubstituted hydrazides.

2016
Yi-Chao Huang Ge-Min Fang Lei Liu

Protein chemical synthesis offers useful and otherwise-difficulty-to-obtain biomacromolecules for biological and pharmaceutical studies. Recently, the hydrazide chemistry has drawn attentions in this field as peptide or protein hydrazides can be used as key intermediates for different synthesis and modification purposes. Besides being a traditional bioorthogonal chemical handle, a hydrazide gro...

Journal: :Organic & biomolecular chemistry 2016
Xia Zhao Tianjiao Li Lipeng Zhang Kui Lu

Iodine-catalyzed thiolation of electron-rich aromatics, including substituted anisole, thioanisole, phenol, toluene, and naphthalene, using sulfonyl hydrazides as sulfenylation reagents was carried out. Sulfonothioates, the products of decomposition of sulfonyl hydrazides in the presence of iodine, are proposed as the major sulfenylation species in this transformation.

2016
Nisha Kumari Naresh Vyas

A simple, efficient, facile and surface mediated method for synthesis of hydrazides of organophosphorous acids has been developed from their corresponding chloridates using calcium oxides as a solid support at room temperature. The developed method gave the desired hydrazides in excellent yields (7592%) and avoids the use of column chromatography.

Journal: :Synlett 2014

Journal: :The Journal of antibiotics 1990
A Trani A Malabarba P Ferrari R Pallanza M Berti R Ciabatti

The condensation of the terminal carboxyl group of the deglucoteicoplanin (TD) with various substituted hydrazines produced hydrazide derivatives having different physico-chemical properties. This chemical modification of the carboxyl function does not affect the ability of teicoplanin antibiotics to interfere in bacterial cell-wall synthesis. The antibacterial activity of deglucoteicoplanin hy...

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