Objectives: To compare the efficacy of intravenous Labetalol and Hydralazine in reduction blood pressure patients with severe pre-eclampsia.
 Methodology: This comparative study was conducted at Department Obstetrics Gynecology Ziauddin University Hospital, Karachi from1st June 2019 to 30th 2020. Total 208 pregnant women having pre-eclampsia (systolic ≥160 mmHg diastolic ≥110mmHg) were inc...

intravenous hydralazine is a commonly administered arteriolar vasodilator that is effective for hypertensive emergencies associated with pregnancy. oral nifedipine is an alternative in management of these patients. in this study the efficacy of nifedipine and hydralazine in pregnancy was compared in a group of iranian patients. fifty hypertensive pregnant women were enrolled in the study. a ran...

Background: Combined hydralazine-nitrate has an avenue in the management of subjects with heart failure reduced ejection fraction. Exploring pharmacotherapy this context will facilitate clinical utility combined therapy. Objective: The main objective mini-review was to evaluate role Methods: We conducted a literature search on Google scholar, MEDLINE, and PubMed identify randomized trials hydra...

Hydralazine is used in the treatment of essential hypertension and is under investigation for epigenetic therapy in the treatment of neoplastic and renal diseases. N-acetyltransferase (NAT) 2 exhibits a common genetic polymorphism in human populations. After recombinant expression in yeast, human NAT2 exhibited an apparent Lineweaver-Burk constant (K-m) value (20.1 ± 8.8 μM) for hydralazine ove...

The antihypertensive drug hydralazine can induce in man a syndrome similar to spontaneous systemic lupus erythematosus (SLE). The pathogenesis of this drug-induced syndrome is not understood. In this investigation, five groups of rabbits were studied: group I, 10 rabbits hyperimmunized with hydralazine conjugated to human serum albumin (HSA) in complete Freund's adjuvant (CFA); group II, four r...

The vasodepressor response to single and multiple oral doses of hydralazine, 1 mg/kg, was studied in hypertensive patients. The concentration of hydralazine in plasma was measured both by a newly developed specific and a nonspecific assay similar to those used in previous studies. Acetylator phenotype was determined following oral sulfamethazine. Plasma hydralazine concentration peaked at 1 hou...

The effects of hydralazine formulation and dose interval were assessed in 20 patients with hypertension well controlled on conventional hydralazine tablets, 100 mg twice daily, in addition to atenolol and a diuretic. The double-blind study used four regimens crossed over in random order at five-week intervals: placebo; conventional hydralazine 100 mg twice daily; conventional hydralazine 200 mg...

Epigenetic therapies have emerged as promising anticancer approaches, since epigenetic modifications play a major role in tumor initiation and progression. Hydralazine, an approved vasodilator and antihypertensive drug, has been recently shown to act as a DNA methylation inhibitor. Even though hydralazine is already tested in clinical cancer trials, its mechanism of antitumor action remains und...

renal response to oral hydralazine therapy in severe heart failure. Circulation 56 (suppl III): 111-9, 1977 33. Birch AA, Boyce WH: Changing renal blood flow following sodium nitroprusside in patients undergoing nephrolithotomy. SUMMARY Hydralazine is known to improve cardiac function in patients with congestive heart failure (CHF), but its effects on renal function in CHF are less clear. Sodiu...

The relative roles of prostaglandins and the sympathetic nervous system in mediating the hypotensive effects of hydralazine were studied in awake dogs with and without pretreatment with indomethacin, propranolol, and phentolamine. In normal dogs, mean aortic pressure decreased 23 +/- 4 mm Hg after administration of hydralazine (cumulative dose of 0.8 mg/kg). This hypotensive effect of hydralazi...