background: the pathogenesis of gestational trophoblastic disease (gtd) is not clearly known. objective: in this study, immunoexpression of proteins bcl-2 and beclin-1 in trophoblastic lesions and normal trophoblastic tissue was conducted to study the mechanism of apoptotic and autophagic cell death that is expected to complete the study of gtd pathogenesis. materials and methods: bcl-2 and bec...

AIMS To investigate the pattern of telomerase activity in hydatidiform mole as compared with normal placenta and choriocarcinoma, and to determine the prognostic significance of telomerase activity in hydatidiform mole. METHODS Telomerase activity in 35 cases of hydatidiform mole, 35 normal placentas, one choriocarcinoma sample, and two choriocarcinoma cell lines (JAR, JEG3) was determined us...

tubal ectopic hydatidiform mole is an uncommon but very important complication of pregnancy. the clinical manifestation is the same as ectopic pregnancy and in all of the cases management was the same as tubal ectopic pregnancy. we present a case of tubal ectopic pregnancy that after laparotomy and salpingectomy, pathologic examination reported hydatidiform mole within ectopic gestational tissu...

BACKGROUND The pathogenesis of Gestational Trophoblastic Disease (GTD) is not clearly known. OBJECTIVE In this study, immunoexpression of proteins Bcl-2 and Beclin-1 in trophoblastic lesions and normal trophoblastic tissue was conducted to study the mechanism of apoptotic and autophagic cell death that is expected to complete the study of GTD pathogenesis. MATERIALS AND METHODS Bcl-2 and Be...

Women with mutation in both alleles of the NLRP7 or C6orf221/KHDC3L genes are predisposed to diploid biparental moles, but it has also been suggested that mutation in these genes can predispose to diploid androgenetic or triploid moles and to other kinds of reproductive wastage. We have investigated the association between molar pregnancy and recurrent miscarriages regarding changes in the NLRP...

Background Gestational trophoblastic disease is a group of benign and malignant entities, where the hydatidiform mole is the most common, and can be divided into complete hydatidiform mole and partial hydatidiform mole. However, the histological criteria are still questionable and also, histologic evaluation alone is prone to great interobserver variability. In this way, inmunohistochemical ana...

initial management, incidence and review of hydatidiform mole, chorioadenoma and destruens and chorio carcinoma in mirza kochek khan hospital department of ob.gyn and gynecology oncology of women's hospital tehran-iran school of medicin from september 1985 to march 1990, 209 patients received primary management for hydatidiform mole at oncology department of mirza kochek khan hospital medi...

p a twin pregnancy with a complete hydatidiform mole with a coexistent foetus (chmf) is a rare condition that typically results in poor pregnancy outcomes. for patients with refractory vaginal bleeding, termination of pregnancy is more appropriate. however, unified methods for termination remain to be explored. in the present study, we reviewed the termination measures in four cases of twin pre...

conclusions our histochemical findings showed a relatively heavy glycosylation of syncytiotrophoblasts of both partial and complete molar tissues, which was prominent in apical portion. this may play a role in their capacity to increase trophoblastic proliferation. results the partial and complete moles generally showed similar reactivity with all used lectins. none of lectins reacted with vill...