Abstract This study aims to find out the way of synthesis, formulas, electronic spectra, magnetic properties, and infrared spectra formed from copper(II) with hydantoin. Copper(II)-hydantoin complex has been synthesized a mole ratio 1:2 metal ligand in methanol. The empirical formula estimated analysis copper content was Cu(hydantoin) 3 SO 4 (H 2 O) n (n = 3, or 5). Electrical conductivity show...

BACKGROUND The general purpose of this study was to deduce the geometry of the bioactive face (pharmacophore) for the hydantoin class of anticonvulsants. METHODS Six hydantoin analogs, selected as probes of hydantoin structure, were synthesized. Nuclear magnetic resonance spectroscopy and molecular modelling calculations were used to determine the geometric relationship between the aromatic g...

Synthesis of (4',5'-diaza-9'-fluorene)-spiro-5-hydantoin: The paper presents a method for synthesis of (4',5'-diaza-9'-fluorene)-spiro-5-hydantoin. The newly obtained compound was synthesized by a treatment of 4,5-diazafluoren-9-one with sodium cyanide, ammonium carbonate, ethanol and ammonium hydroxide at high pressure and high temperature. The structure of (4',5'-diaza-9'-fluorene)-spiro-5-hy...

In recent years, microwave irradiation using commercial domestic ovens for the optimization and acceleration of organic reactions has rapidly increased1−2.It has been reported that a variety of reactions such as Dielsalder , ene, Claisen reactions , Fischer cyclization, synthesis of heterocycles , hydrolysis of esters , hydrogenation, deprotection of benzyl ester, deacetylation of diacetates, o...

A DNA fragment from Microbacterium liquefaciens AJ 3912, containing the genes responsible for the conversion of 5-substituted-hydantoins to alpha-amino acids, was cloned in Escherichia coli and sequenced. Seven open reading frames (hyuP, hyuA, hyuH, hyuC, ORF1, ORF2, and ORF3) were identified on the 7.5 kb fragment. The deduced amino acid sequence encoded by the hyuA gene included the N-termina...

3,5-Disubstituted hydantoin (1,3-imidazolidinedione) derivatives 5a-h were prepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-L- and D-amino acid amides 4a-h. Compounds 5a-h were evaluated for their cytostatic and antiviral activities. Among all the compounds evaluated, 3-benzhydryl-5-isopropyl hydantoin (5a) showed a weak but selective inhibitory effect again...

Multidrug resistance has become a factor seriously limiting treatment of various diseases, including bacterial (1ñ3) and fungal (4) infections and cancer (5ñ7). The major mechanism of multidrug resistance (MDR) in cancer is the over-expression of ATP-dependent drug-efflux pumps (drug transporters), which reduces the accumulation of agents. One of the most important mechanisms of MDR in cancer i...

In 1912 Lewis (1) administered hydantoin to rabbits, cats, and dogs and came to the conclusion that the ring was not readily broken in the body. Gaebler and Keltch (2) some years later showed that some hydantoin was excreted as hydantoic acid after injection into dogs. Wada (3) claimed that urea was produced from hydantoin after incubation with milk or certain tissue suspensions. Finally, Kozel...

The gene hyuP from Microbacterium liquefaciens AJ 3912 with an added His6 tag was cloned into the expression plasmid pTTQ18 in an Escherichia coli host strain. The transformed E. coli showed transport of radioisotope-labeled 5-substituted hydantoins with apparent K(m) values in the micromolar range. This activity exhibited a pH optimum of 6.6 and was inhibited by dinitrophenol, indicating the r...

The hydantoin racemase gene of Pseudomonas sp. strain NS671 had been cloned and expressed in Escherichia coli. Hydantoin racemase was purified from the cell extract of the E. coli strain by phenyl-Sepharose, DEAE-Sephacel, and Sephadex G-200 chromatographies. The purified enzyme had an apparent molecular mass of 32 kDa as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. ...