Mitomycin C is one of the most effective chemotherapeutic agents for a wide spectrum of cancers, but its clinical use is still hindered by the mitomycin C (MMC) delivery systems. In this study, the MMC-loaded polymer-lipid hybrid nanoparticles (NPs) were prepared by a single-step assembly (ACS Nano 2012, 6:4955 to 4965) of MMC-soybean phosphatidyhlcholine (SPC) complex (Mol. Pharmaceutics 2013,...

Amplification of DNA in vivo occurs in intracellular environments characterized by macromolecular crowding (MMC). In vitro Polymerase-chain-reaction (PCR), however, is non-crowded, requires thermal cycling for melting of DNA strands, primer-template hybridization and enzymatic primer-extension. The temperature-optima for primer-annealing and extension are strikingly disparate which predicts pri...

The interlinking converters is one of the important components in hybrid mirogrid system, study structure and control method has been implemented achieved positive results. This paper proposes an improved decentralized level-shifted carrier-based PWM for a modular multilevel converter (IC-MMC) standalone microgrid (HMG-Hybrid Microgrid). Main research objectives to capability proposed IC-MMC un...

This paper proposes a hybrid submodule modular multilevel converter (MMC) topology which is suitable for multi terminal direct current (MTDC) transmission systems. Each arm of the proposed MMC consists half-bridge (HBSM) branch and two parallel full-bridge (FBSM) branches. Comparing with conventional MTDC system, can selectively block DC fault isolate corresponding line without expensive circui...

Aiming to address the growth and integration of renewable sources electronic loads, different types dc-dc topologies with specific features have been proposed, going from medium frequency isolated Modular Multilevel Converter Switched Capacitor Hybrid topologies. In this paper, a bidirectional based converter is presented, featuring transformerless structure, automatic total arm voltages clampi...

This project use migrating means clustering unsupervised classification (MMC), maximum likelihood classification (MLC) trained by picked training samples and trained by the results of unsupervised classification (Hybrid Classification) to classify a 512 pixels by 512 lines NOAA-14 AVHRR Local Area Coverage (LAC) image. All the channels including ch3 and ch3t are used in this project. The image ...

In the hybrid modular multilevel converter (MMC) based high voltage direct current (HVDC) systems, fault can be actively suppressed by itself, which endows a smaller requirement for current-limiting reactors (CLR) and larger time margin detection algorithms, comparing with half-bridge MMC. But robustness to resistance noise disturbance of existing boundary protection schemes will deteriorated s...

Three Mitomycin C (MMC)-hypersensitive mutants (CL-V1B, CL-V5B, and CL-V101B) were isolated from Chinese hamster V79B cells by the replica plating technique. In comparison to the parental cell line, CL-V1B, CL-V5B, and CL-V101B show about a 22-, 32-, and 13-fold increased sensitivity to MMC, respectively (judged by the D10). These mutants are also sensitive to other DNA cross-linking agents, su...

Combination chemotherapy is frequently used in the clinic for cancer treatment; however, associated adverse effects to normal tissue may limit its therapeutic benefit. Nanoparticle-based drug combination has been shown to mitigate the problems encountered by free drug combination therapy. Our previous studies have shown that the combination of two anticancer drugs, doxorubicin (DOX) and mitomyc...