background: infection with parvovirus b19 may cause fetal losses including spontaneous abortion, intrauterine fetal death and non-immune hydropsfetalis. the aim of this study is to determine the frequency of parvovirus b19 in formalin fixed placental tissues in lost fetuses using real-time pcr method.   methods : in this cross-sectional study, 100 formalin fixed placental tissues with unknown c...

Human Leukocyte Antigens (HLA) of fetus are responsible for induction of HLA antibodies in mother. Exposure to the mismatched paternal HLA antigens in the fetus gives rise to a polyclonal antibody response against paternal HLA antigens. HLA antibodies are present in the maternal circulation of the placenta and are absorbed onto the placenta [1]. The major source of HLA antisera is from sera of ...

Objective(s):Mesenchymal stem cells (MSC) can be isolated from adult tissues such as adipose tissue and other sources. Among these sources, adipose tissue (because of easy access) and placenta (due to its immunomodulatory properties, in addition to other useful properties), have attracted more attention in terms of research. The isolation and comparison of MSC from these two sources provides a ...

background: placenta previa (pp) is an obstetric complication that can affect maternal and fetal morbidity and mortality. its prevalence is rising due to cesarean sections. there is no quantitative data of placenta in pp. in this study, quantitative parameters of placenta in cases with pp in comparison with normally implanted controls were investigated. methods: in this quasi experimental study...

The chorioallantoic placenta connects mother and fetus in eutherian pregnancies. In order to understand the evolution of the placenta and provide further understanding of placenta biology, we sequenced the transcriptome of a term placenta of an African elephant (Loxodonta africana) and compared these data with RNA sequence and microarray data from other eutherian placentas including human, mous...

The human placenta exhibits unique structural and multifunctional features. It is known to have the capacity to synthesize, store and secrete hormones of the hypothalamohypophyseal axis, but the existence of neurotransmitters and neuropeptides in the human placenta has attracted a great deal of attention. This is especially important when it is considered that the placenta is a non-innervated o...

The activity of monoamine oxidase (MAO), an enzyme which metabolized catecholamines and indoleamines, was determined in rat placenta at various stages of gestation, in human term placenta, and in choriocarcinoma grown in culture. From Day 15 to Day 20 of gestation the specific activity (units/mg protein) of MAO in rat placenta increased at least 3-fold; from Day 20 to the time of parturition, i...

Ex v/vo addition of estradiol 1713 to first trimester or term human placental minces caused a significant increase in the quantity of progesterone produced. Addition of an aromatase inhibitor, CGS 16949 A, or the estrogen receptor antagonist, ICI 182780, significantly inhibited progesterone production confirming the role of estradiol 1713 in the regulation of progesterone synthesis in human pla...