نتایج جستجو برای: Human antibody library

تعداد نتایج: 1863887  

Journal: :acta medica iranica 0
a a. jafari

after using 3 different generations of antibodies including human and non-human hyperimmune sera, monoclonal antibodies and chimeric antibodies, more recently a newer approach has been developed in which the antibody genes are cloned directly from a patient peripheral b-lymphocytes and expressed in a host like e. coli. in this study the candida albicans serotype a (nctc 3153) mannan was purifie...

2014
Marcel Weber Emil Bujak Alessia Putelli Alessandra Villa Mattia Matasci Laura Gualandi Teresa Hemmerle Sarah Wulhfard Dario Neri

Several synthetic antibody phage display libraries have been created and used for the isolation of human monoclonal antibodies. The performance of antibody libraries, which is usually measured in terms of their ability to yield high-affinity binding specificities against target proteins of interest, depends both on technical aspects (such as library size and quality of cloning) and on design fe...

Journal: :Biochemical and biophysical research communications 2006
Hae-Won Lee Seung-Hyun Lee Kyung-Jin Park Jeong-Sun Kim Myung-Hee Kwon Yong-Sung Kim

Lymphocytes from eight individuals out of 60 healthy donors, whose plasmas showed relatively higher antibody titer for a target antigen of death receptor 5 (DR5), were selected for the source of antibody genes to construct so called an anti-DR5 pseudo-immune human single-chain fragment variable (scFv) library on the yeast cell surface (approximately 2x10(6) diversity). Compared with a large non...

Journal: :archives of razi institute 2016
m.h. motedayen g. nikbakht m.j. rasaee a. zare mirakabadi

human snake bitten poisoning is a serious threat in many tropical and subtropical countries such as iran. the best acceptable treatment of envenomated humans is antivenoms; however they have a series of economic and medical problems and need more improvements. in this study a combinatorial human immunoglobulin gene library against some of iranian snakes venoms was constructed. total rna prepare...

A. Zare Mirakabadi G. Nikbakht M.H. Motedayen M.J. Rasaee

Human snake bitten poisoning is a serious threat in many tropical and subtropical countries such as Iran. The best acceptable treatment of envenomated humans is antivenoms; however they have a series of economic and medical problems and need more improvements. In this study a combinatorial human immunoglobulin gene library against some of Iranian snakes venoms was constructed. Total RNA prepare...

Journal: :Separation and Purification Technology 2021

Antibody technologies are the most representative success-case in biopharmaceutical industry. Widely available purification fail providing a dedicated universal platform that can accommodate antibodies structural diversity, namely from non-human sources, as chicken IgY, and antigen-binding fragments. In this work, we took inspiration natural engineered antibody-binding ligands, to rationally de...

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2007
Kunihiko Itoh

Phage display has been utilized for making recombinant antibody fragments (Fab or single chain Fv) of human, mouse, or other origins. After construction of an antibody combinatorial library, antigen-specific recombinant antibody fragments can be easily isolated by biopanning of the phage library displaying antibody fragment fused with viral coat protein III against antigen proteins, antigen-exp...

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