objective(s) the present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice. materials and methods antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests. results promethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant inhi...

the present study is a designed protocol for investigation of the analgesic effect of oral and intraperitoneal (i.p.) administration of alcoholic datura stramonium (ds) seed extract as a rich source of alkaloid substances. male nmri rats were divided into control and treatment groups. the treatment rats received different doses of the ds seed extract, which was prepared from alcoholic smashed s...

this study was designed to investigate the role of gabab receptor agents on imipramine-induced antinociception in ligated and non-ligated mice using hot-plate test. the data showed that different doses of morphine (3, 6, and 9 mg/kg) induced a dose-dependent antinociception in ligated and non-ligated mice. however, the opioid response was decreased in ligated animals. intracerebroventricular (i...

objective: the present study was designed to investigate the analgesic effect of oral and i.p. administration of alcoholic viscum album (v.a) fruit extract as a rich source of alkaloid substances. materials and methods: experimented animals were divided into control and treatment groups. the treatment rats received different doses of the v.a fruit extract, which was prepared from alcoholic sma...

pistacia vera l., a member of anacardiaceae family, has been used for sedation and analgesia in traditional medicine. in this study, the antinociceptive and anti-inflammatory effects as well as acute toxicity of the aqueous and ethanolic extracts of p. vera leaves were investigated in mice. the antinociceptive activity was studied using hot plate and writhing tests. the effect of the extracts a...

the antinociceptive effect of elaeagnus angustifolia fruits was studied in mice. the antinociceptive effect of ethanolic and boiling water extracts was studied using two thermal stimuli, the hot-plate and tail-flick tests. the intraperitoneal and oral administration of the ethanolic extract of seed 0.75-7.00 g/kg), but not pericarp and medulla had significant antinociceptive activity in the hot...