نتایج جستجو برای: Histone H1

تعداد نتایج: 54763  

Journal: :Nucleic acids research 1997
S Schwarz D Hess J P Jost

The methylated DNA binding protein-2-H1 (MDBP-2-H1), present in rooster liver, is a member of the histone H1 family which inhibits transcription by binding selectively to methylated promoters. Here we have determined the primary structure of MDBP-2-H1. A comparison between histone H1 and MDBP-2-H1 was achieved by analyzing reversed phase HPLC-purified and V8-digested proteins by mass spectromet...

2008
Anna Gréen

.................................................................................................. 10 POPULÄRVETENSKAPLIG SAMMANFATTNING............................. 12 PAPERS IN THE PRESENT THESIS ....................................................... 15 ABBREVIATIONS ....................................................................................... 16 INTRODUCTION..........................

Journal: :Development 1992
H J Clarke C Oblin M Bustin

We have examined the distribution of histone H1 in oocytes and preimplantation embryos of the mouse, using a polyclonal antibody raised against the histone H1 subtypes present in somatic cells. Immunofluorescence and immunoblotting analyses failed to detect somatic histone H1 in germinal vesicle (GV)-stage oocytes. In contrast, somatic histone H1 was detectable by immunofluorescence in the nucl...

2013
Nikhil Raghuram Hilmar Strickfaden Darin McDonald Kylie Williams He Fang Craig Mizzen Jeffrey J. Hayes John Th’ng Michael J. Hendzel

Histone H1 plays a crucial role in stabilizing higher order chromatin structure. Transcriptional activation, DNA replication, and chromosome condensation all require changes in chromatin structure and are correlated with the phosphorylation of histone H1. In this study, we describe a novel interaction between Pin1, a phosphorylation-specific prolyl isomerase, and phosphorylated histone H1. A su...

Seyed Zahra Bathaie, Sorour Shojaeian,

The linker histones (H1 or H5) which play a key role in the folding of chromatin, are general repressors of gene expression. Nuclei of the mature chicken erythrocytes (and in some mammalian cells) contain both of them. Although the interaction of H5 with DNA is stronger than that of H1, it does not prevent the transcription of some erythroid-specific genes. It has been shown that some modificat...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Bibhudatta Mishra Maren von der Ohe Christian Schulze Shan Bian Tatjana Makhina Gabriele Loers Ralf Kleene Melitta Schachner

Polysialic acid (PSA) is a large and highly negatively charged glycan that plays crucial roles in nervous system development and function in the adult. It has been suggested to facilitate cell migration, neurite outgrowth, and synaptic plasticity because its hydration volume could enhance flexibility of cell interactions. Evidence for receptors of PSA has so far been elusive. We now identified ...

Journal: :The Biochemical journal 1981
V Giancotti S Cosimi P D Cary C Crane-Robinson G Geraci

The separation and purification of histone H1 from the sperm of the sea-urchin Sphaerechinus granularis is described. Physical studies were used to compare this histone H1 molecule with H1 histones from other species. C.d. and 270 MHz n.m.r. spectroscopy indicate that, despite significant compositional differences from other sea-urchin sperm H1 histones, their secondary and tertiary structures ...

Journal: :Mechanisms of Development 1998
Fabio Spada Adeline Brunet Yvan Mercier Jean-Paul Renard Marco E. Bianchi Eric M Thompson

High mobility group 1 protein (HMG1) has traditionally been considered a structural component of chromatin, possibly similar in function to histone H1. In fact, at the onset of Xenopus and Drosophila development, HMG1 appears to substitute for histone H1: HMG1 is abundant when histone H1 is absent after the midblastula transition histone H1 largely replaces HMG1. We show that in early mouse emb...

Journal: :Nucleic acids research 1996
L Halmer C Gruss

We have reconstituted salt-treated SV40 minichromosomes with differentially phosphorylated forms of histone H1 extracted from either G0-, S- or M-phase cells. Sedimentation studies revealed a clear difference between minichromosomes reconstituted with S-phase histone H1 compared with histone H1 from G0- or M-phase cells, indicating that the phosphorylation state of histone H1 has a direct effec...

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