experimental work was carried out to investigate the influence of impeller speed, granulation time, binder mass and their interactions on granule size distribution, mean size and binder content distribution in a conical high shear granulator. it was observed that the response of high shear granulation to changes in process parameters varies significantly from one operating condition to another....

High-shear and fluid-bed processes were used for granulation of dolomite powder into agrochemical product. In this paper, comparative study of the granulation process focuses on the observation of granule size distribution (GSD). Considerable difference between high-shear and fluid-bed GSDs is analyzed with process kinetics. Simulation of dynamic development of GSD is achieved with application ...

sion/spheronization affects the properties of the resulting pellets. Pharmaceutical scientists originally directed their focus to extrusion, spheronization and drying which can be seen from the literature. Only a few authors reported investigations concerning the impact of the granulation step. Baert et al. investigated ternary mixtures of microcrystalline cellulose (MCC), a drug substitute and...

There are different dynamic or static test methodologies for evaluating the shear and torsional moduli of wood. A preferred method is nondestructive, accurate, and standard. However, dynamic methods using conventional devices previously suggested for determining the orthotropic shear moduli of wood are neither accurate nor standard. Thus, a reliable method for evaluating the torsional modulus o...

A newly developed mini-scale high shear granulator was used for scale-up study of wet granulation process from 0.2 to 200 L scales. Under various operation conditions and granulation bowl sizes, powder mixture composed of anhydrous caffeine, D-mannitol, dibasic calcium phosphate, pregelatinized starch and corn starch was granulated by adding water. The granules were tabletted, and disintegratio...

Purpose: As in-line process analytics are becoming more widely accepted, it is important to illustrate that a measurement of interest will provide the expected outcome if that control point has reached a desired level. This methodology is especially true for novel applications. The purpose of this work was to investigate the role of densification during high shear granulation and the resulting ...

Granule breakage is an important rate process in wet granulation that promotes product uniformity and controls size strength. In this work, a model to predict granule proposed experimentally validated. The assumes exponential of the surviving granules, dependent on probability breakage; function powder binder properties, as well operating parameters. Validation experiments were performed with b...

The roles of grain boundaries and twin boundaries in mechanical properties are well understood for metals and alloys. However, for covalent solids, their roles in deformation response to applied stress are not established. Here we characterize the nanotwins in boron suboxide (B6O) with twin boundaries along the {0111} planes using both scanning transmission electron microscopy and quantum mecha...

Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. Granulation process transforms fine powders into free-flowing, dust-free granules that are easy to compress. Nevertheless, granulation poses numerous challenges due to high quality requirement o...