objective(s): hyperglycemia, oxidative stress and apoptosis have key roles in pathogenesis of diabetic neuropathy. there are local renin-angiotensin systems (rass) in different tissues such as neural tissue. local rass are involved in physiological and pathophysiological processes such as inflammation, proliferation and apoptosis. this study aimed to investigate the role of local renin-angioten...

objective(s):the aim of this study was to evaluate, for the first time, whether the effects of low-dose adropin administration is effective in rats with hyperlipidemia. materials and methods: twenty one wistar albino female rats were randomly divided into 3 groups and fed with high-fat diet for 4 weeks to establish the hyperlipidemia model. meanwhile, adropin was administrated intraperitonealy ...

background: high fasting plasma glucose (fpg) is one of the main leading risk factors of ischemic heart disease (ihd), stroke, and chronic kidney diseases (ckds). we estimated population attributable fraction (paf) and attributed death of these fatal outcomes of high fpg at national and subnational levels in 25–64 years old iranian adult. methods: we used national and subnational data of the no...

background: clinical evidence indicates the diabetes-induced impairment of osteogenesis caused by a decrease in osteoblast activity. flavonoids can increase the differentiation and mineralization of osteoblasts in a high-glucose state. however, some flavonoids such as luteolin may have the potential to induce cytotoxicity in osteoblast-like cells. this study was performed to investigate whether...

background: hyperglycemia is one of the important featurs of diabetes. in cell culture studies different methods are used to mimic the hyperglycemia condition. in this study we investigate response of human liver cancer cell line (hepg2) to high insulin, high glucose, and high insulin/ high glucose medium exposure. methods: hepg2 cells were settled in dmem+0.1% fbs or dmem free-serum medium wit...

stem cell therapy could have great potential for the treatment of a wide variety of diseases. stem cells might have the ability to differentiate into a widespread cell types, and to repopulate and revitalize the damaged cells with healthy tissue, and improve its performance. we provide here the evidence supporting the critical use of stem cell as a treatment in disease conditions existing with ...

objective: type 2 diabetes (t2d) as a complex disease is the result of genetically heterogeneous factors and environmental issues interaction. linkage and small-scale candidate gene studies were successful in identification of genetic susceptibilities of monogenic form of diseases. however, they were largely unsuccessful while applying to the more common forms of disease. by designing genome wi...

Low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (MAPK) signaling pathways. It has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (CGNs). In this study, we have examined the activation of JNK, p38kinase and ERK1/2 pathways in low glucose medium in CGNs. The CGNs were prepared ...