نتایج جستجو برای: High dose modified release tablets

تعداد نتایج: 2662461  

Journal: :Journal of clinical pharmacology 2013
Hartmut Derendorf Klaus Ruebsamen Lynsey Clarke Achim Schaeffler John R Kirwan

In rheumatoid arthritis (RA), nocturnal release of proinflammatory cytokines is not adequately counteracted by endogenous glucocorticoid and is associated with symptoms of morning stiffness and pain. Taking exogenous glucocorticoid during the night reduces morning stiffness significantly more than treatment at the conventional time in the morning, although waking to take tablets is unacceptable...

2015
GOPA ROY

The aim of the current investigation is to study the kinetics of drug release pattern from buccal swellable, controlled release tablets of amoxicillin trihydrate. Buccal tablets were prepared with modified gum karaya in 5-20% concentration. Drug release from the formulated amoxicillin trihydrate loaded buccal tablets followed Zero order kinetics resulting in regulated and controlled release for...

Journal: :iranian journal of pharmaceutical sciences 0
saini nish school of pharmaceutical sciences, shoolini university solan (h.p), india george mathew school of pharmaceutical sciences, shoolini university solan (h.p), india joseph lincy school of pharmaceutical sciences, shoolini university solan (h.p), india

the purpose of this review article is to characterize all of the parameters regarding the types, polymers used, and release kinetics of matrix tablets. matrix system was the earliest oral extended release platform for medicinal use. matrix tablets are most commonly used methods to modulate the release profile of drugs. they are much desirable and preferred for such therapy because they offer be...

2014
Adenike Okunlola

Bilayer tablets of aceclofenac sodium were developed using carboxymethylated white yam (Dioscorea rotundata) starch (CWY) for a fast release layer (2.5, 5.0, and 7.5% w/w), and acid-hydrolyzed bitter yam (Dioscorea dumetorum) starch (ABY) for a sustaining layer (27% w/w). Sodium starch glycolate (SSG) and hydroxypropyl methyl cellulose (HPMC) were used as standards. The starches were characteri...

2011
Mithilesh Kumar Jha Md. Habibur Rahman Md. Mofizur Rahman

The manufacture of bi-layer tablets, produced by the sequential compaction of loose powder layers has recently become of increased interest within the pharmaceutical industry due to the tailored release profiles of active ingredients that may be obtained. In a bi-layer configuration, the immediate release layer of the bilayer tablet has worked as the loading dose and the sustained release layer...

2015
Alvaro Goyanes Asma B.M. Buanz Abdul W. Basit Simon Gaisford

25 The use of fused-filament 3D printing (FF 3DP) to fabricate individual tablets is 26 demonstrated. The technology permits the manufacture of tablets containing drug 27 doses tailored to individual patients, or to fabrication of tablets with specific drug-28 release profiles. Commercially produced polyvinyl alcohol (PVA) filament was loaded 29 with a model drug (Fluorescein) by swelling of th...

Guaifenesin, a highly water-soluble active (50 mg/mL), classified as a BCS class I drug.Owing to its poor flowability and compressibility, formulating tablets especially high-dose one,may be a challenge. Direct compression may not be feasible. Bilayer tablet technology appliedto Mucinex®, endures challenges to deliver a robust formulation. To overcome challengesinvolved in bilayer-tablet manufa...

George Mathew Joseph Lincy Saini Nish,

       The purpose of this review article is to characterize all of the parameters regarding the types, polymers used, and release kinetics of matrix tablets. Matrix system was the earliest oral extended release platform for medicinal use. Matrix tablets are most commonly used methods to modulate the release profile of drugs. They are much desirable and preferred for such therapy because they o...

Guaifenesin, a highly water-soluble active (50 mg/mL), classified as a BCS class I drug.Owing to its poor flowability and compressibility, formulating tablets especially high-dose one,may be a challenge. Direct compression may not be feasible. Bilayer tablet technology appliedto Mucinex®, endures challenges to deliver a robust formulation. To overcome challengesinvolved in bilayer-tablet manufa...

2012
Parnapalli Malathi Arshad Bashir Khan

Bilayered tablet is an important pharmaceutical technology for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablet is suitable for sequential release of two drugs in combination, to separate incompatible substances and also formulating sustained release tablet in which one layer is immediat...

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