Chamomile, a well-known medicinal plant, is a rich source of bioactive compounds, among which two coumarin derivatives, umbelliferone and herniarin, are often found in its extracts. Chamomile extracts have found a different uses in cosmetic industry, as well as umbelliferone itself, which is, due to its strong absorption of UV light, usually added to sunscreens, while herniarin (7-methoxycoumar...

BACKGROUND Umbelliferone, also known as 7-hydroxycoumarin, is a phenolic metabolite found in many familiar plants. Its derivatives have been shown to have various pharmacological and chemo-preventive effects on human health. A uridine diphosphate glycosyltransferase YjiC from Bacillus licheniformis DSM 13, a cytochrome P450BM3 (CYP450 BM3) variant namely mutant 13 (M13) from Bacillus megaterium...

OBJECTIVE 7-prenyloxycoumarins are a group of secondary metabolites that are found mainly in plants belonging to the Rutaceae and Umbelliferae families. This study was designed to evaluate and compare the cytotoxic and apoptotic activity of 7-prenyloxycoumarin compounds and herniarin on MCF-7, a breast carcinoma cell line. MATERIALS AND METHODS Cells were cultured in RPMI medium and incubated...

objective(s) 7-prenyloxycoumarins including 7-isopentenyloxycoumarin, auraptene and umbelliprenin, and herniarin have been widely recognized as bioactive coumarins. this paper presents the ways to synthesis these compounds. materials and methods 7-prenyloxycoumarins were synthesized by reaction between 7-hydroxycoumarin (' m) and relevant prenyl bromides (1.5 m) in acetone at room temperat...

Background: Ischemia causes severe neuronal damage and induces oxidative stress, memory impairment, reduces pain threshold. Herniarin is a powerful antioxidant. Objectives: This study aimed to evaluate the effect of herniarin on memory, pain, stress in an ischemia model male rats. Materials & Methods: In this study, 50 rats were divided into 5 groups control, sham, ischemic, two other ische...

The study of the chemical constituents of the whole plant of Geranium wallichianum (Geraniaceae) has resulted in the isolation and characterization of six compounds. These six compounds were identified as ursolic acid (1), β-sitosterol (2), stigmasterol (3), β-sitosterol galactoside (4), herniarin (5), and 2,4,6-trihydroxyethylbenzoate (6) which were isolated for the first time from Geranium wa...

Objectives: 7-prenyloxycoumarins are a group of secondary metabolites that are found mainly in plants belonging to the Rutaceae and Umbelliferae families. This study was designed to evaluate and compare the cytotoxic and apoptotic activity of 7-prenyloxycoumarin compounds and herniarin on MCF-7, a breast carcinoma cell line. Materials and Methods: Cells were cultured in RPMI medium and incubate...

Objective(s) 7-prenyloxycoumarins including 7-isopentenyloxycoumarin, auraptene and umbelliprenin, and herniarin have been widely recognized as bioactive coumarins. This paper presents the ways to synthesis these compounds. Materials and Methods 7-prenyloxycoumarins were synthesized by reaction between 7-hydroxycoumarin (' M) and relevant prenyl bromides (1.5 M) in acetone at room temperatur...

objectives: 7-prenyloxycoumarins are a group of secondary metabolites that are found mainly in plants belonging to the rutaceae and umbelliferae families. this study was designed to evaluate and compare the cytotoxic and apoptotic activity of 7-prenyloxycoumarin compounds and herniarin on mcf-7, a breast carcinoma cell line. materials and methods: cells were cultured in rpmi medium and incubate...

BackgroundHerniarin, a simple coumarin found in chamomile leaf rosettes is known as the oxidative stress protector. In current study, herniarin was captured into Graphene oxide nanoparticles and coated with chitosan poly-cationic polymer to be used novel bio-compatible nano-drug delivery system investigate its antioxidant, anti-angiogenic anti-cancer impacts on human lung A549 cancer cells.Meth...