Hepatoid variant of yolk sac tumor of ovary is an unusual tumor with an aggressive behavior. It is usually observed in young females, presents with abdominal complaints and is associated with raised α-fetoprotein (AFP) levels. It should be differentiated from other hepatoid tumors involving the ovary. A complete patient evaluation with gross, microscopy, and immunohistochemistry can identify th...

Hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphological similarities to hepatocellular carcinoma. Hepatoid adenocarcinoma of the stomach is a cancer with an extremely poor prognosis with few cases reported. Here, we describe a 75-year-old Spanish man referred to our hospital with a history of abdominal pain, general fatigue, anorexia and sickness. Initial study revealed ...

AIMS To investigate a potential diagnostic use of alpha fetoprotein (alpha FP) isoform analysis by lectin affinity electrophoresis to distinguish between endodermal sinus tumours arising in the vagina in infants from those at other sites. METHODS alpha FP in the serum of a patient with a vaginal endodermal sinus tumour was analysed for its isoforms by lectin affinity electrophoresis. The isof...

This report is of a 44-year-old woman with an α -foetoprotein–producing rectal adenocarcinoma. At presentation, her serum α-foetoprotein was 158,334 μg/L, and investigation excluded other causes, such as gynaecological malignancy, hepatocellular carcinoma, germ cell tumour, or hepatoid adenocarcinoma. The patient developed early distant metastasis despite treatment with 5-fluorouracil-based che...

The present study evaluated the expression of claudin-7 in 10 intact perianal gland and 67 hyperplastic and neoplastic lesions of the canine perianal (hepatoid) gland. The results have shown intense typical membrane expression of claudin-7 in intact perianal glands, hyperplasia, adenoma, differentiated and anaplastic carcinoma of this gland. In intact glands, hyperplasias, adenomas of the hepat...

Hepatoid adenocarcinoma is a special type of extrahepatic adenocarcinoma that morphologically mimics hepatocellular carcinoma (HCC). Clinical and immunohistochemical features of hepatoid adenocarcinoma are similar to those of HCC, such as elevated serum alpha-fetoprotein (AFP) level, immunoreactivity with AFP, polyclonal carcinoembryonic antigen (CEA), and alpha-1 antitrypsin. Because of these ...

INTRODUCTION Hepatoid adenocarcinoma is a special type of extrahepatic alpha-fetoprotein-producing adenocarcinoma, which has a morphologic similarity to hepatocellular carcinoma. We report a patient with underlying hepatitis B virus infection and hepatoid adenocarcinoma with liver metastasis mimicking hepatocellular carcinoma. CASE PRESENTATION We present the case of a 56-year-old Chinese fem...

Hepatoid adenocarcinoma is a very rare disease and usually occurs in the stomach, ovaries lungs. The term hepatoid was first introduced by Ishikura et al. 1985 to describe aggressive malignant neoplasm urinary bladder [1,3].

Thirty nine canine adnexal tumours were histologically and immunohistochemically analysed. They were classified as trichoblastomas, trichoepitheliomas, sebaceous adenomas and epitheliomas, hepatoid gland adenomas and epitheliomas, and aporcine adenocarcinomas. Moreover, hepatoid gland angioadenoma and angioepithelioma were recognised. Studies of follicular tumours revealed coexpression of cytok...

Hepatoid adenocarcinoma is a rare variant of extrahepatic adenocarcinoma which behaves like hepatocellular carcinoma in morphology and functionality. We present a rare case of hepatoid adenocarcinoma of the gallbladder which invades deeply the liver bed, in a 59-year-old woman. Histologically, most of the mass in the gallbladder was composed of cells with eosinophilic cytoplasm arranged in a tr...