objective(s) the effect of berberis vulgaris aqueous extract in hepatocarcinogenic rats was studied to investigate the apoptotic and sodium, potassium elements properties. a loss of both intracellular potassium and sodiumoccurs when apoptotic cells shrink and prior to the loss of membraneintegrity. materials and methods forty-eight sprague dawley rats were randomly divided into 2 groups, normal...

Autophagy has opposite effects on hepatocarcinogenesis depending on whether it occurs before or after its onset. Autophagy prevents the initiation of hepatocarcinogenesis by suppressing oxidative stress and DNA damage. However, it also inhibits cell death and the expression of tumor suppressors to promote tumor progression once hepatocarcinogenesis has been initiated.

Hepatocellular carcinoma is the third most frequent cause of cancer-related death worldwide; and its incidence rate is increasing. Clinical and molecular medical analyses have revealed substantial information on hepatocarcinogenesis. Hepatocarcinogenesis is a stepwise process during which multiple genes are altered. Genetic changes and their biological consequences in human HCC can be divided i...

Recent studies have revealed that angiogenesis plays a pivotal role in carcinogenesis and tumor growth. We previously reported that the clinically used vitamin K2 (VK) and angiotensin-converting enzyme inhibitor (ACE-I) exerted potent anti-angiogenic activities. The aim of our current study was to examine the combination effect of VK and ACE-I on hepatocarcinogenesis induced by diethyl-nitrosam...

The phenomenon of gender disparity is very profound in hepatocellular carcinoma (HCC). Although previous research has revealed important roles microRNA (miRNA) HCC, there are no studies investigating the role miRNAs observed hepatocarcinogenesis. In present study, we investigated global miRNAomics changes related to Ras -induced male-prevalent hepatocarcinogenesis a Hras12V -transgenic mouse mo...

Background and Aim: Cancer stem cells (CSCs) have been proposed as a driving force of tumor initiation, dissemination drug resistance. The protease inhibitor SerpinB3 (SB3) has involved in the early events hepatocarcinogenesis, is highly expressed hepatic progenitor cells. However, only limited information on possible role SB3 cholangiocarcinoma (CCA) stem-like compartment available.

Hepatocellular carcinoma (HCC) is a male-dominant disease with poor prognosis. Sorafenib is the only approved systemic chemotherapeutic drug for patients with advanced HCC. Previous studies have shown that androgen and androgen receptor (AR) are involved in human hepatocarcinogenesis and the development of HCC. Here, we discuss the recent data on AR and HCC, and the combination of sorafenib and...

The expression of cellular myc (c-myc) was studied during early and late stages of chemical hepatocarcinogenesis in the rat using Northern blot analysis and in situ hybridization. Hepatocarcinogenesis was induced according to the resistant hepatocyte model of Solt and Farber. An uninitiated version of this model was also used to examine the expression of c-myc during proliferation and different...

BACKGROUND To define the NF-kappaB activation in early stages of hepatocarcinogenesis and its IkappaB's degradation profiles in comparison to sole liver regeneration. METHODS Western-blot and EMSA analyses were performed for the NF-kappaB activation. The transcriptional activity of NF-kappaB was determined by RT-PCR of the IkappaB-alpha mRNA. The IkappaB's degradation proteins were determined...