conclusions non-invasive assessment of hepatic fibrosis could be done using the egy-score. egy-score could differentiate no or early fibrosis (stage f0-f2 metavir) from severe fibrosis or cirrhosis (stage f3 - f4 metavir) with 83.7% accuracy. results combined elevation of ca 19-9 and ca 125 with a summated value > 37 u/ml is predictive of severe hepatic fibrosis or cirrhosis (stage f3-f4 metavi...

hepatitis c virus (hcv) infection causes chronic hepatitis, which frequently leads to hepatic fibrosis and hepatocellular carcinoma (hcc). alanine aminotransferase (alt) is a biomarker of hepatocyte injury and is associated with the progression of hepatic fibrosis. advanced hepatic fibrosis also predisposes hcv carriers to a risk of hcc. in contrast, some cases with persistent hcv infection hav...

objective(s):to clarify the protective effects of cichorium glandulosum (cg) extracts on thioacetamide (taa)-induced rat hepatic fibrosis. materials and methods: the dry roots of cg were smashed and percolated with 95% ethanol, and the residual was prepared into petroleum ether extract (cg-v), ethyl acetate extract (cg-vi) and n-butyl alcohol extract (cg-vii). thirty-six wistar rats were random...

the influence of glycosaminoglycans (gag) on collagen fibrillogenesis in vitro was investigated. gag and collagen were isolated from the liver of rats treated with carbon tetrachloride at various time intervals (3-16 weeks). it was found that gag obtained from the fibrotic liver accelerated collagen fibril formation. this effect was more evident in a solution of type i collagen than type iii co...

Background: The renin-angiotensin system has an important role in hepatic inflammation and fibrosis. Renin-angiotensin system blockade by angiotensinconverting enzyme (ACE) inhibitors provides some protective effects against hepatic fibrogenesis. Captopril as an ACE inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (BDL) rats. Object...

aim : in this study, to clarify the smad4blocking impact on fibrosis process, we investigated its down-regulation by shrna on activated human lx-2 cell, in vitro.   background : liver fibrosis is a critical consequence of chronic damage to the liver that can progress toward advanced diseases, liver cirrhosis and hepatocellular carcinoma (hcc).  different smad proteins play as major mediators in...

background hepatic fibrosis is a typical complication of chronic liver diseases resulting in cirrhosis that remains a major public health problem worldwide. liver biopsy is currently the gold standard for diagnosing and staging hepatic fibrosis. percutaneous liver biopsy; however, is an invasive procedure with risks of complications. therefore, there is need for alternative non-invasive techniq...

background: the renin-angiotensin system has an important role in hepatic inflammation and fibrosis. renin-angiotensin system blockade by angiotensinconverting enzyme (ace) inhibitors provides some protective effects against hepatic fibrogenesis. captopril as an ace inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (bdl) rats. object...