نتایج جستجو برای: Hemocyanins

تعداد نتایج: 116  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1995
T Kawabata Y Yasuhara M Ochiai S Matsuura M Ashida

Pro-phenol oxidase [pro-PO; zymogen of phenol oxidase (monophenol, L-dopa:oxygen oxidoreductase, EC 1.14.18.1)] is present in the hemolymph plasma of the silkworm Bombyx mori. Pro-PO is a heterodimeric protein synthesized by hemocytes. A specific serine proteinase activates both subunits through a limited proteolysis. The amino acid sequences of both subunits were deduced from their respective ...

Journal: :Integrative and comparative biology 2007
Heinz Decker Nadja Hellmann Elmar Jaenicke Bernhard Lieb Ulrich Meissner Jürgen Markl

This review summarizes recent highlights of our joint work on the structure, evolution, and function of a family of highly complex proteins, the hemocyanins. They are blue-pigmented oxygen carriers, occurring freely dissolved in the hemolymph of many arthropods and molluscs. They are copper type-3 proteins and bind one dioxygen molecule between two copper atoms in a side-on coordination. They p...

Journal: :Molecular biology and evolution 1997
G Durstewitz N B Terwilliger

The complete cDNA sequence and protein reading frame of a developmentally regulated hemocyanin subunit in the Dungeness crab (Cancer magister) is presented. The protein sequence is aligned with 18 potentially homologous hemocyanin-type proteins displaying apparent sequence similarities. Functional domains are identified, and a comparison of predicted hydrophilicities, surface probabilities, and...

Journal: :The Journal of Experimental Medicine 1939
Arne Tiselius Frank L. Horsfall

By means of the improved electrophoretic technique it has been possible to study the association products which are formed when mixed and dissociated hemocyanins from two different species are reassociated. Both the dissociation and the reassociation of the hemocyanins have been produced simply by altering the pH of the solutions. Scale method electrophoretic diagrams have been used throughout ...

2017
Javier Pizarro-Bauerle Ismael Maldonado Eduardo Sosoniuk-Roche Gerardo Vallejos Mercedes N. López Flavio Salazar-Onfray Lorena Aguilar-Guzmán Carolina Valck Arturo Ferreira María Inés Becker

Molluskan hemocyanins are enormous oxygen-carrier glycoproteins that show remarkable immunostimulatory properties when inoculated in mammals, such as the generation of high levels of antibodies, a strong cellular reaction, and generation of non-specific antitumor immune responses in some types of cancer, particularly for superficial bladder cancer. These proteins have the ability to bias the im...

Journal: :Revista medica de Chile 2011
Miguel Del Campo Sergio Arancibia Esteban Nova Fabián Salazar Andrea González Bruno Moltedo Pablo De Ioannes Jorge Ferreira Augusto Manubens María Inés Becker

Hemocyanins, the giant oxygen transporter glycoproteins of diverse mollusks, are xenogenic to the mammalian immune system and they display a remarkable immuno-genicity. Therefore they are ideal non-specific immunostimulants to treat some types of cancer. They are used as an alternative therapy for superficial urinary bladder cancer (SBC), that has been traditionally treated with Bacillus Calmet...

2015
Dessislava Nikolova

The active site of Viviparus ater (mollusc) hemocyanin was investigated using the fact that the binding of dioxygen to the binuclear copper-containing sites of hemocyanins is connected with the appearance of specific dichroic bands which are very sensitive to changes in the structrure and polarity of the environment. Oxy-Viviparus ater hemocyanin exhibits near UV and visible circular dichroism ...

Journal: :Molecular biology and evolution 2009
Beyhan Ertas Björn M von Reumont Johann-Wolfgang Wägele Bernhard Misof Thorsten Burmester

The Remipedia are enigmatic crustaceans from anchialine cave systems, first described only 30 years ago, whose phylogenetic affinities are as yet unresolved. Here we report the sequence of hemocyanin from Speleonectes tulumensis Yager, 1987 (Remipedia, Speleonectidae). This is the first proof of the presence of this type of respiratory protein in a crustacean taxon other than Malacostraca. Spel...

Journal: :The FEBS journal 2005
Mariano Beltramini Nadia Colangelo Folco Giomi Luigi Bubacco Paolo Di Muro Nadja Hellmann Elmar Jaenicke Heinz Decker

The hemocyanin of the tiger shrimp, Penaeus monodon, was investigated with respect to stability and oxygen binding. While hexamers occur as a major component, dodecamers and traces of higher aggregates are also found. Both the hexamers and dodecamers were found to be extremely stable against dissociation at high pH, independently of the presence of calcium ions, in contrast to the known crustac...

2014
Sergio Arancibia Cecilia Espinoza Fabián Salazar Miguel Del Campo Ricardo Tampe Ta-Ying Zhong Pablo De Ioannes Bruno Moltedo Jorge Ferreira Ed C. Lavelle Augusto Manubens Alfredo E. De Ioannes María Inés Becker

Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as immunomodulatory proteins with proven anti-cancer properties. The biodiversity of hemocyanins has promoted interest in identifying new anti-cancer candidates with improved immunological properties. Hemocyanins promote Th1 responses without known side effects, which make them ideal for long-term sustained treat...

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