spinal cord injury (sci) leads to a significant health problem associated with a broad range of secondary complications and disabilities. in this regard, animal models can help us to understand the pathobiology of sci and evaluate the effects of potential treatments for sci. in contusion models of sci, different devices including surgical spring-loaded clips, balloons, forceps, weights and the ...

Cervical spinal cord injury (SCI) can result in devastating functional deficits that involve the respiratory and hand function. The mammalian spinal cord has limited ability to regenerate and restore meaningful functional recovery following SCI. Riluzole, 2-amino-6-trifluoromethoxybenzothiazole, an anti-glutamatergic drug has been shown to reduce excitotoxicity and confer neuroprotection at the...

33 After incomplete spinal cord injury (SCI), compensatory changes occur 34 throughout the whole neuraxis including the spinal cord below the lesion as suggested by 35 previous experiments using a dual SCI paradigm. Indeed, cats submitted to a lateral 36 spinal hemisection at T10-11 and trained on a treadmill for 3-14 weeks re-expressed 37 bilateral hindlimb locomotion as soon as 24 hours after...

While many studies have focused on modulating the immune response and enhancing axonal regeneration after spinal cord injury (SCI), there is limited work being performed on evaluating the role of glial scar in SCI. We sought to evaluate the effects of glial scar resection in contusion models and dorsal hemisection models of SCI. At 1-week postinjury, 2 mm of glial scar was excised from specimen...

Spinal cord injury (SCI) has serious long-term consequences on sympathetic cardiovascular regulation. Orthostatic intolerance results from insufficient baroreflex regulation (BR) of sympathetic outflow to maintain proper blood pressure upon postural changes. Autonomic dysreflexia occurs due to insufficient inhibition of spinal sources of sympathetic activity. Both of these conditions result fro...

Heat shock proteins (HSPs) are specifically induced by various forms of stress. Hsp70.1, a member of the hsp70 family is known to play an important role in cytoprotection from stressful insults. However, the functional role of Hsp70 in motor function after spinal cord injury (SCI) is still unclear. To study the role of hsp70.1 in motor recovery following SCI, we assessed locomotor function in h...

The spontaneous axon regeneration of damaged neurons is limited after spinal cord injury (SCI). Recently, mesenchymal stem cell (MSC) transplantation was proposed as a potential approach for enhancing nerve regeneration that avoids the ethical issues associated with embryonic stem cell transplantation. As SCI is a complex pathological entity, the treatment of SCI requires a multipronged approac...

AIM Autophagy is an important process that balances cellular protein synthesis and degradation and is involved in many physiological and pathological conditions. However, the precise role of autophagy has not yet been defined in the model of spinal cord injury (SCI). MATERIAL AND METHODS Here, we utilized a hemisection model of acute SCI to elucidate the role of autophagy in the pathological ...

High spinal cord injuries (SCI) lead to permanent respiratory insufficiency, and the search for new therapeutics restore this function is essential. To date, most documented preclinical model high SCI rat cervical C2 hemisection. However, molecular studies with are limited due poor availability of genetically modified specimens. The aim work was evaluate pathophysiology activity following a inj...

Spinal cord injury (SCI) is damage to the spinal cord that leads to sudden loss of motor and autonomic function and sensory under the level of the injury. Studies showed that individuals with SCI has a clear tendency to vitamins level change. The aim of this study was to review the vitamins level in spinal cord injury. Vitamins C level decrease in the injured spinal cord patient. Vitamins C hav...