introduction: allogeneic hematopoietic cell transplantation (hsct) is the only therapeutic modality capable of correcting the hematologic manifestations of fanconi anemia (fa). the development  of well  tolerated,  immunosuppressive  conditioning  regimens  for fa patients  undergoing hsct has proven to be a rather challenging task for hematologists. methods: we analyzed the outcome of 30 fa pa...

conclusions in iran, hsct has been successfully adapted in routine clinical care. recently, new methods such as double cord blood and haploidentical transplantation have been used to treat many life-threatening diseases. results about 78.2% of the patients (2530 of 3237) remained alive between one to 211 months after stem cell transplantation. nearly, 21.8% (707) of our patients died after stem...

the increased risk of hemolytic reactions and erythrocyte recovery delay in abo incompatible hematopoietic stem cell transplantation (hsct) is well established. effects of abo incompatibility on transplantation outcomes is evaluated in this study. we prospectively followed 501 patients undergoing allogeneic stem cell transplantation according to abo compatibility groups of minor, major and bidi...

hematopoietic stem/progenitor cells (hspcs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. interacting factors such as stromal derived factor-1/cxcr4, very late antigen-4/vascular cell adhesion molecule-1, lymphocyte function-associated antigen-1/ intercellular adhesion molec...

background: today, hematopoietic stem cells transplantation (hsct) has been accepted as a therapeutic approach and is widely applied in many patients with disorders of hematopoietic systems or patients with malignancies. concomitant use of this therapeutic approach with long term chemotherapeutic procedures and hospitalization requires special care. this study was conducted to examine basic nee...

background: this study explored the state of hematopoietic stem cell transplantation (hsct) recipient patients and problems experienced by them and nurse about these state and problems, in iran. methods: qualitative content analysis was used for analyzing semi-structured interviews with 12 hsct recipient patients and 18 nurses. results: three main categories described the hsct state and problem...

hematopoietic stem cell transplantation (hsct) has been practiced for more than 30 years. hematological malignanciesare the main indications for this treatment. however, its indications in adults are different from children.advances in chemotherapy and target therapy have improved treatment outcome of some of the very high riskcancers, and changed indications of hsct in children. multi-center c...

introduction: human hematopoietic stem cells (hhscs) have been used for transplantation in hematologic failures. because the number of hhscs per cord blood unit is limited, the expansion of these cells is important for clinical application. it has been reported that cytokines and feeder layer provide a perspective to in vitro expansion of hhscs. in this regard, cord blood cd34+ cells expanded a...

Objective(s): High-risk neuroblastoma is a childhood cancer with poorprognosis despite modern multimodality therapy. Internal radiotherapy using131I-metaiodobenzylguanidine (MIBG) is effective for treating the disease even if it isresistant to chemotherapy. The aim of this study is to evaluate the safety and efficacyof 131I-MIBG radiotherapy combined with myeloablative high-dose chemotherapyand...

introduction: accumulating evidences indicated that during increasing of the animals' age, the number and the functional properties of hematopoietic stem cells (hscs) become altered because of a gradual decrease in replication potential.  the efficient factors in this process are dna damaging, reduced telomerase activity, shortening of telomeres and oxidative stresses. for overcoming these fact...