Background and aim: Basal cell carcinoma (BCC) is the most common cancer in humans. Activation of Hedgehog (Hh) signal has a key role in development of BCC. The end result of Hedgehog signal are Gli proteing. Gli 1 is a member of this family which activates DNA transcription. Previous studies showed increased expression of Gli 1 in BCC.Materials and methods: In this study 38 pathologic samples ...

ates Ptc from Smo (Figure 1B) is also generally enter-Daniel Kalderon* tained (Chen and Struhl, 1996) because it is countered Department of Biological Sciences only by a single observation of Ptc-mediated binding of Columbia University Hh to Smo in tissue culture cells that expressed high New York, New York 10027 levels of both vertebrate Ptc and Smo (Stone et al., 1996). Some new data support ...

The Hedgehog signal transducer Smoothened is structurally similar to G protein-coupled receptors. Now there is direct evidence that Smoothened relies on heterotrimeric G proteins in order to transduce the Hedgehog signal.

The hedgehog signal pathway is an essential agent in developmental patterning, wherein the local concentration of the Hedgehog morphogens directs cellular differentiation and expansion. Furthermore, the Hedgehog pathway has been implicated in tumor/stromal interaction and cancer stem cell. Nowadays searching novel inhibitors for Hedgehog Signal Pathway is drawing much more attention by biologic...

The arrival of retinal axons in the brain of Drosophila triggers the assembly of glial and neuronal precursors into a 'neurocrystalline' array of lamina synaptic 'cartridges'. Hedgehog, a secreted protein, is an inductive signal delivered by retinal axons for the initial steps of lamina differentiation. In the development of many tissues, Hedgehog acts in a signal relay cascade via the inductio...

Protein kinase A activity is required for signalling by the extracellular molecule Hedgehog in developing Drosophila imaginal discs, but does the kinase actually respond to the Hedgehog signal?

Ventral cell fates in the central nervous system are induced by Sonic hedgehog, a homolog ofhedgehog, a secreted Drosophila protein. In the central nervous system, Sonic hedgehog has been identified as the signal inducing floor plate, motor neurons, and dopaminergic neurons. Sonic hedgehog is also involved in the induction of ventral cell type in the developing somites. ptc is a key gene in the...