In order to investigate the molecular diversity of mtDNA in Azeri population, 133 Azeri subjects inhabitingdifferent regions of Azerbaijan (Iran) were selected. Blood samples were taken from these subjects formtDNA extraction. The extracted mtDNA samples were then studied by the PCR-RFLP method.Fourteen haplogroups were characterized from which 82% were identified as European ...

alzheimer’s disease (ad) is the most common form of dementia in the elderly in which interplay between genes and the environment is supposed to be involved. mitochondrial dna (mtdna) has the only non-coding regions at the displacement loop (d-loop) region that contains two hypervariable segments (hvs-i and hvs-ii) with high polymorphism. mtdna has already been fully sequenced and many subsequen...

BACKGROUND MtDNA haplogroups could have important implication for understanding of the relationship between the mutations of the mitochondrial genome and diseases. Distribution of a variety of diseases among these haplogroups showed that some of the mitochondrial haplogroups are predisposed to disease. To examine the susceptibility of mtDNA haplogroups to ROU, we sequenced the mtDNA HV1, HV2 an...

More than a half of the northern Asian pool of human mitochondrial DNA (mtDNA) is fragmented into a number of subclades of haplogroups C and D, two of the most frequent haplogroups throughout northern, eastern, central Asia and America. While there has been considerable recent progress in studying mitochondrial variation in eastern Asia and America at the complete genome resolution, little comp...

BACKGROUND Traffic-related air pollution has been linked with impaired cognition in older adults, possibly due to effects of oxidative stress on the brain. Mitochondria are the main source of cellular oxidation. Haplogroups in mitochondrial DNA (mtDNA) mark individual differences in oxidative potential and are possible determinants of neurodegeneration. The aim of this study was to investigate ...

Low-coverage short-read resequencing experiments have the potential to expand our understanding of Y chromosome haplogroups. However, the uncertainty associated with these experiments mean that haplogroups must be assigned probabilistically to avoid false inferences. We propose an efficient dynamic programming algorithm that can assign haplogroups by maximum likelihood, and represent the uncert...

Controversy surrounds the relationship between the Eastern African M1 haplogroup and Indian M haplogroups. Some researchers see a “relationship” between the Eastern African M1 and Indian M haplogroups,[1-3] while other researchers maintain that the Eastern African HVS-I signature motif 16,129, 16,189, 16,249, and 16,311,[4] is not found in Indian M haplogroups, and this results from “parallel m...

Y-chromosomal (Y-DNA) haplogroups are more widely used in population genetics than in genetic epidemiology, although associations between Y-DNA haplogroups and several traits, including cardiometabolic traits, have been reported. In apparently homogeneous populations defined by principal component analyses, there is still Y-DNA haplogroup variation which will result from population history. The...

Only a limited number of complete mitochondrial genome sequences belonging to Native American haplogroups were available until recently, which left America as the continent with the least amount of information about sequence variation of entire mitochondrial DNAs. In this study, a comprehensive overview of all available complete mitochondrial DNA (mtDNA) genomes of the four pan-American haplogr...