We previously reported that a serotonin precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice. In this study, we studied the effects of insulin and adrenalectomy on hyperleptinemia induced by 5-HTP. Co-administration of insulin significantly increased hyperleptinemia elicited by 5-HTP. 5-HTP itself increased serum insulin levels. Adrenalectomy, which depletes corticosteron...

The relationship between molecular geometries, crystal structures and charge mobilities of hexathiapentacene (HTP) three its derivatives (2Se-HTP, 4Se-HTP, 6Se-HTP) were studied using the density functional theory combined with a hopping mechanism at level. effect Se substitution on mobility was discussed. calculated results showed that exhibit good planarity geometries show little variation du...

Giving L-tryptophan, serotonin's circulating precursor, or a serotonin-releasing drug can decrease food intake and body weight. Giving 5-hydroxy-L-tryptophan (5-HTP), serotonin's immediate intracellular precursor, has been thought to be ineffective in enhancing brain serotonin synthesis unless it is coadministered with a dopa decarboxylase inhibitor to protect 5-HTP from destruction outside the...

The Histidine Triad Proteins (HTPs), also known as Pht proteins in Streptococcus pneumoniae, constitute a family of surface-exposed proteins that exist in many pathogenic streptococcal species. Although many studies have revealed the importance of HTPs in streptococcal physiology and pathogenicity, little is known about their origin and evolution. In this study, after identifying all htp homolo...

For a ring R, Hilbert’s Tenth Problem HTP (R) is the set of polynomial equations over R, in several variables, with solutions in R. We view HTP as an operator, mapping each set W of prime numbers to HTP (Z[W−1]), which is naturally viewed as a set of polynomials in Z[X1, X2, . . .]. For W = ∅, it is a famous result of Matiyasevich, Davis, Putnam, and Robinson that the jump ∅′ is Turing-equivale...

HTP is an SMT Modulo theorem prover similar to many others.[2–6, 9, 11] As input, HTP accepts problems using the SMT-LIB format[8]. As output, HTP will answer either SAT, UNSAT or UNKNOWN. Alternatively, HTP can be run in a preprocessing mode in which the output is the simplified problem in SMTLIB format. An evidence file showing the derivation in a human readable form can be produced. There is...

Effect of L-5-HTP (L-5-hydroxytryptophane) on the release of human growth hormone (HGH), thyroid stimulating hormone (TSH) and immunoreactive insulin (IRI) was investigated in 7 normal subjects and 25 patients with endocrine disorders. A single oral dose of 200mg of L-5-HTP showed the elevation of HGH in plasma; however, no release of TSH and insulin in plasma of normal subjects. HGH response t...

Background. Fat affects gastric emptying (GE). 5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms. Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated. Subjects/Methods. 24 healthy individuals (12f : 12m, 22-29 years, BMI 19-25.7 kg/m²) were tested on 4 days with either 5-HTP + short-chain ...

Clinical reports indicate that patients with allergy/asthma commonly have associated symptoms of anxiety/depression. Anxiety/depression can be reduced by 5-hydroxytryptophan (5-HTP) supplementation. However, it is not known whether 5-HTP reduces allergic inflammation. Therefore, we determined whether 5-HTP supplementation reduces allergic inflammation. We also determined whether 5-HTP decreases...

AIM To investigate the involvement of L-type Ca(2+) channels in antinociceptive action induced by the 5-HT precursor, 5-hydroxytryptophan (5-HTP). METHODS Female Kunming mice were treated with either 5-HTP (20-80 mg/kg, ip) alone, or the combination of 5-HTP and fluoxetine (2-8 mg/kg, ip), pargyline (15-60 mg/kg, ip), nimodipine (2.5-10 mg/kg, ip), nifedipine (2.5-10 mg/kg, ip), verapamil (2....