نتایج جستجو برای: HSP25

تعداد نتایج: 193  

2013
Kimberly A. Huey Carolyn A. Hilliard Clayton R. Hunt

Aging is associated with an adverse decline in muscle function, often manifesting as decreased strength and increased muscle fatigability that negatively affects the overall health of the elderly. Heat shock proteins (HSPs), a family of stress inducible proteins known to protect cells from damage, are highly induced in muscle cells following exercise, but both basal and inducible levels decline...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2008
Elaine O Petrof Mark W Musch Mae Ciancio Jun Sun Michael E Hobert Erika C Claud Andrew Gewirtz Eugene B Chang

Flagellin is a bacterial protein responsible for activation of Toll-like receptor 5 (TLR5), which we hypothesize is involved in Salmonella's induction of cytoprotective heat shock proteins in intestinal epithelial cells. Flagellin induces the cytoprotective heat shock protein Hsp25 in different intestinal epithelial cell lines and in mouse intestine. Flagellin induces Hsp25 expression in a time...

Journal: :American journal of physiology. Renal physiology 2005
Sahoko Hirano Xiankui Sun Cheryl A DeGuzman Richard F Ransom Kenneth R McLeish William E Smoyer Eric A Shelden Michael J Welsh Rainer Benndorf

The environmental pollutant cadmium affects human health, with the kidney being a primary target. In addition to proximal tubules, glomeruli and their contractile mesangial cells have also been identified as targets of cadmium nephrotoxicity. Glomerular contraction is thought to contribute to reduced glomerular filtration, a characteristic of cadmium nephrotoxicity. Because p38 MAPK/HSP25 signa...

Journal: :Journal of applied physiology 2006
Kimberly A Huey

Functional overload (FO) is a powerful inducer of muscle hypertrophy and both oxidative and mechanical stress in muscle fibers. Heat shock protein 25 (HSP25) may protect against both of these stressors, and its expression can be regulated by changes in muscle loading and activation. The primary purpose of the present study was to test the hypothesis that chronic FO increases HSP25 expression an...

Journal: :Journal of applied physiology 2007
Kimberly A Huey Gary E McCall Hui Zhong Roland R Roy

Early events in response to abrupt increases in activation and loading with muscle functional overload (FO) are associated with increased damage and inflammation. Heat shock protein 25 (HSP25) may protect against these stressors, and its expression can be regulated by muscle loading and activation. The purpose of this study was to investigate the responses of HSP25, phosphorylated HSP25 (pHSP25...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2006
Kuljit Parhar Kathy A Baer Kristy Parker Mark J Ropeleski

Although short-chain fatty acid (SCFA)-induced heat shock protein 25 (Hsp25) is associated with increased cellular resistance to injury, withdrawal of lumenal butyrate in vivo is associated with intestinal epithelial injury and apoptosis. Recognizing that SCFA-dependent posttranslational modification of Hsp25 may involve altered Hsp25 phosphorylation, we hypothesized that butyrate regulates Hsp...

Journal: :Journal of the American Society of Nephrology : JASN 2000
W E Smoyer R Ransom R C Harris M J Welsh G Lutsch R Benndorf

AlphaB-crystallin and heat shock protein (hsp) 25 are structurally and functionally related small stress proteins induced by a variety of insults, including heat and ischemia. Cytoprotection by these two hsp is thought to result from molecular chaperoning and/or cytoskeletal stabilization. Because renal ischemia is characterized by disruption of the renal tubular cell actin cytoskeleton, this s...

2017
Ji-Eun Kim Hye-Won Hyun Su-Ji Min Tae-Cheon Kang

Heat shock protein (HSP) 25 (murine/rodent 25 kDa, human 27 kDa) is one of the major astroglial HSP families, which has a potent anti-apoptotic factor contributing to a higher resistance of astrocytes to the stressful condition. However, impaired removals of HSP25 decrease astroglial viability. In the present study, we investigated whether HSP25 is involved in astroglial apoptosis or clasmatode...

Journal: :The Journal of biological chemistry 2002
Dongho Geum Gi Hoon Son Kyungjin Kim

The present study examined phosphorylation-dependent cellular localization and the thermoprotective role of heat shock protein (HSP) 25 in hippocampal HiB5 cells. HSP25 was induced and phosphorylated by heat shock (at 43 degrees C for 3 h). HSP25, which was located in the cytoplasm in the normal condition, translocated into the nucleus after the heat shock. Transfection experiments with hsp27 m...

Journal: :Journal of radiation research 2006
Hang-Rhan Seo Hee-Yong Chung Yoon-Jin Lee Sangwoo Bae Su-Jae Lee Yun-Sil Lee

Thermoresistant (TR) clone of radiation-induced fibrosarcoma (RIF) cells have been reported to show adaptive response to 1 cGy of low dose radiation, and hsp25 and inducible hsp70 are involved in this process. In the present study, to further elucidate the mechanism of how hsp25 and inducible hsp70 regulate the adaptive response, hsp25 or inducible hsp70 overexpressed RIF cells were irradiated ...

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