نتایج جستجو برای: HSA nanoparticle

تعداد نتایج: 34300  

2016
Sandesh Chibber Irshad Ahmad

BACKGROUND We study the human serum albumin (HSA) protein-CuO nanoparticle interaction to identify the specific binding site of protein with CuO nanoparticles by molecular docking and compared it with HSA-TiO2 nanoparticle interaction. METHODS The protein structural data that was obtained using Autodock 4.2. RESULTS In case of CuO np-HSA interaction, the distances from the centre of Subdoma...

Journal: :Applied physics letters 2012
Ran Chen Poonam Choudhary Ryan N Schurr Priyanka Bhattacharya Jared M Brown Pu Chun Ke

The physical interaction between a lipid vesicle and a silver nanoparticle (AgNP)-human serum albumin (HSA) protein "corona" has been examined. Specifically, the binding of AgNPs and HSA was analyzed by spectrophotometry, and the induced conformational changes of the HSA were inferred from circular dichroism spectroscopy. The fluidity of the vesicle, a model system for mimicking cell membrane, ...

2016
Xinzhe Yu Yunlong Song Yang Di Hang He Deliang Fu Chen Jin

The emerging albumin nanoparticle brings new hope for the delivery of antitumor drugs. However, a lack of robust tumor targeting greatly limits its application. In this paper, cyclic arginine-glycine-aspartic-conjugated, gemcitabine-loaded human serum albumin nanoparticles (cRGD-Gem-HSA-NPs) were successfully prepared, characterized, and tested in vitro in the BxPC-3 cell line. Initially, 4-N-m...

2009

The aim of present study was to prepare human serum albumin (HSA) nanoparticle for drug delivery. These nanoparticles were prepared by desolvation method. The body distribution of colloidal drug delivery systems was mainly influenced by two physicochemical properties namely particle size and surface characteristics. The influence of several factors on the fabrication process including the pH va...

2017
Liewei Wen Sihua Yang Junping Zhong Quan Zhou Da Xing

Multifunctional nanoparticle-mediated imaging and therapeutic techniques are promising modalities for accurate localization and targeted treatment of cancer in clinical settings. Thermoacoustic (TA) imaging is highly sensitive to detect the distribution of water, ions or specific nanoprobes and provides excellent resolution, good contrast and superior tissue penetrability. TA therapy is a poten...

2014
MOHD JAHIR KHAN MOHAMAD YUSOF MASKAT

Objective: The present study is designed to investigate the interaction of titanium dioxide nanoparticle (TiO2NPs) with human serum albumin (HSA) using spectroscopic techniques. Methods: TiO2NPs was characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and Fourier transform infrared (FTIR) spectroscopy. Effect of NPs on the conformation of HSA was evaluated by ...

2011
Qiu-Sha Tang Dao-Zhen Chen Wen-Qun Xue Jing-Ying Xiang Yong-Chi Gong Li Zhang Cai-Qin Guo

BACKGROUND The purpose of this study was to develop intraperitoneal hyperthermic therapy based on magnetic fluid hyperthermia, nanoparticle-wrapped cisplatin chemotherapy, and magnetic particles of albumin. In addition, to combine the multiple-killing effects of hyperthermal targeting therapy, chemotherapy, and radiotherapy, the albumin-nanoparticle surfaces were linked with radionuclide (188)R...

2012
Sana Abbasi Arghya Paul Wei Shao Satya Prakash

Most anticancer drugs are greatly limited by the serious side effects that they cause. Doxorubicin (DOX) is an antineoplastic agent, commonly used against breast cancer. However, it may lead to irreversible cardiotoxicity, which could even result in congestive heart failure. In order to avoid these harmful side effects to the patients and to improve the therapeutic efficacy of doxorubicin, we d...

2012
Xiaojun Tao Qiufang Zhang Kai Ling Yicun Chen Wenzhi Yang Fenfei Gao Ganggang Shi

Nanoparticle (NP) compositions such as hydrophobicity and surface charge are vital to determine the presence and amount of human serum albumin (HSA) binding. The HSA binding influences drug release, biocompatibility, biodistribution, and intercellular trafficking of nanoparticles (NPs). Here, we prepared 2 kinds of nanomaterials to investigate HSA binding and evaluated drug release of HSA-bound...

Journal: :Pharmaceutics 2021

The aim of this study was to develop an intranasal in situ thermo-gelling meloxicam-human serum albumin (MEL-HSA) nanoparticulate formulation applying poloxamer 407 (P407), which can be administered liquid state into the nostril, and increase resistance against mucociliary clearance by sol-gel transition on nasal mucosa, as well improve drug absorption. Nanoparticle characterization showed that...

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