the purpose of this study was to develop a new monolithic matrix tablet to completely deliver glipizide in a zero order manner over a sustained period. two approaches were examined using drug in a formulation that contain polymer like hydroxylpropyl methyl-cellulose k 100 (hpmck) and eudragit l 100. the granules were prepared by wet granulation method and thereby formulated as f-1, f-2. f-3 and...

An attempt was made to formulate Buccal patches of Isoxsuprine hydrochloride, a potent and long acting vasodilator and uterine suppressant , by using Hydroxyl propyl methyl cellulose(HPMC), Polyvinyl pyrolidone K-30 (PVP K-30) and Hydroxyl ethyl cellulose (HEC). Twelve batches of buccal patches were prepared by solvent casting technique in which the best formulation was found out. The polymers ...

        Controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (HPMC) as the matrix former. The effects of the viscosity grades of HPMC and HPMC/lactose ratio and ethylcellulose (EC)/sodium carboxymethylcellulose (NaCMC) and their concentrations on the release behavior of phenobarbital from HPMC matrices wer...

In this study, an injectable bone substitute (IBS) consisting of citric acid, chitosan, and hydroxyl propyl methyl cellulose (HPMC) as the liquid phase and tetra calcium phosphate (TTCP), dicalcium phosphate dihydrate (DCPD) and calcium sulfate dehydrate (CSD, CaSO4 x 2H2O) powders as the solid phase, were fabricated. Two groups were classified based on the percent of citric acid in the liquid ...

Background: A special hydroxypropylmethylcellulose powder (Nasaleze®) has been used for the alleviation of nasal symptoms of allergic rhinitis since 1994. The efficacy of the product has been recently proven but the mechanism of action was still largely unknown. The aim of the study was to investigate the hypothesis that the gel formed after moisture absorption in the nose might act as mechanic...

controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (hpmc) as the matrix former. the effects of the viscosity grades of hpmc and hpmc/lactose ratio and ethylcellulose (ec)/sodium carboxymethylcellulose (nacmc) and their concentrations on the release behavior of phenobarbital from hpmc matrices were invest...

The integrity of the mesothelial layer is essential for both defence and solute transport in continuous ambulatory peritoneal dialysis (CAPD). The human peritoneal mesothelial cell (HPMC) culture has been shown to be a very useful tool to study the peritoneal mesothelial stem cell behaviour. We investigated whether hydralazine, an antihypertensive agent frequently used, might affect HPMC growth...

In the present work, monolithic matrix transdermal systems containing Drug x were prepared using various ratios of the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit S 100 (ES) with triethyl citrate as a plasticizer. A 32 full factorial design was employed. The concentration of HPMC and ES were used as independent variables, while percentage drug release was selected as d...

The aim of the current study was to design an oral sustained release matrix tablet of metformin HCl and to optimize the drug release profile using response surface methodology. Tablets were prepared by non-aqueous wet granulation method using HPMC K 15M as matrix forming polymer. A central composite design for 2 factors at 3 levels each was employed to systematically optimize drug release profi...