pregabalin (prg) is a new antiepileptic drug and aceclofenac (ace) is a potent non-steroidal anti-inflammatory drug. these drugs in combination are used for treatment of partial seizures and neuropathic pains. a simple and precise assay method by rp-hplc was developed and validated for estimation of prg and ace in acenac-n tablet. analyses of commercial tablet, acenac-n were performed using jas...

passiflora species were known by their anticonvulsant, anxiolytic and sedative activities. the aim of this study was to investigate the chemical composition of the most active leaf extract of passiflora caerulea l. grown in egypt. the ethanolic extract of the leaves exhibited higher activity than aqueous extract as anticonvulsant (63% potency relative to carbamazepine), analgesic (70% potency r...

This work proposes a procedure to estimate the measurement uncertainty for the quantification of cefazolin by high-performance liquid chromatography (HPLC) and microbiological assay (bioassay). HPLC method was performed according to United States Pharmacopeia (USP) and bioassay according to Brazilian Pharmacopeia (FB). The quantification of cefazolin by high-performance liquid chromatography wa...

A improved, simple and economic reverse phase high performance liquid chromatography (RP-HPLC) method has been developed and validated as per ICH guidelines for the quantification of acetic acid present in Gefitinib as an solvent impurity. Validation studies demonstrated that the proposed RP-HPLC method is simple, specific, rapid, reliable and reproducible. The high recovery and low relative st...

this paper describes two rapid, sensitive and specific methods for the determination of fulvestrant in pharmaceutical preparations by high performance liquid chromatography (hplc) and linear sweep voltammetry (lsv). hplc method was used to study the degradation behaviour. fulvestrant was subjected to degradation under the conditions of hydrolysis (acid and alkali), oxidation (30% h2o2). the lin...

This paper describes two rapid, sensitive and specific methods for the determination of fulvestrant in pharmaceutical preparations by high performance liquid chromatography (HPLC) and linear sweep voltammetry (LSV). HPLC method was used to study the degradation behaviour. Fulvestrant was subjected to degradation under the conditions of hydrolysis (acid and alkali), oxidation (30% H2O2). The lin...

A simple high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) method for screening and quantification of ricinine in feeds is established for use in feed quality control. Ricinine is extracted from the sample with methanol. The sample extract is directly used for screening with LC-MS and is cleaned up using solid-phase extraction for quantification w...