نتایج جستجو برای: HPI

تعداد نتایج: 776  

Journal: :The Journal of biological chemistry 1985
D E Peavy M R Brunner W C Duckworth C S Hooker B H Frank

The biological activities of several derivatives of human proinsulin (HPI) containing peptide bond cleavages or peptide deletions in the connecting peptide region were examined in vivo in rats and in several in vitro systems. The two derivatives which were tested in vivo, split (32-33)HPI and des-(64,65)HPI, both demonstrated greater potency in lowering blood glucose than did intact HPI. The re...

Journal: :Infection and immunity 1999
A Rakin C Noelting S Schubert J Heesemann

Yersinia pestis, Y. pseudotuberculosis O:1, and Y. enterocolitica biogroup 1B strains carry a high-pathogenicity island (HPI), which mediates biosynthesis and uptake of the siderophore yersiniabactin and a mouse-lethal phenotype. The HPI of Y. pestis and Y. pseudotuberculosis (Yps HPI) are highly conserved in sequence and organization, while the HPI of Y. enterocolitica (Yen HPI) differs signif...

Journal: :ACS chemical biology 2015
Jean Ndjomou M Josie Corby Noreena L Sweeney Alicia M Hanson Cihan Aydin Akbar Ali Celia A Schiffer Kelin Li Kevin J Frankowski Frank J Schoenen David N Frick

This study examines the specificity and mechanism of action of a recently reported hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase-protease inhibitor (HPI), and the interaction of HPI with the NS3 protease inhibitors telaprevir, boceprevir, danoprevir, and grazoprevir. HPI most effectively reduced cellular levels of subgenomic genotype 4a replicons, followed by genotypes 3a and 1...

2003
Zhi-Song Qiao Cheng-Yin Min Qing-Xin Hua Michael A. Weiss You-Min Feng

Human insulin is a double-chain peptide that is synthesized in vivo as a single-chain human proinsulin (HPI). We have investigated the disulfide-forming pathway of a single-chain porcine insulin precursor (PIP). Here we further studied the folding pathway of HPI in vitro. While the oxidized refolding process of HPI was quenched, four obvious intermediates (namely P1, P2, P3, and P4, respectivel...

Journal: :Polish journal of microbiology 2012
Ryszard Koczura Joanna Mokracka Adam Kaznowski

We examined 12 pairs of strains of Escherichia coli and Klebsiella pneumoniae isolated from mixed infections in human for the presence of the Yersinia high-pathogenicity island (HPI). In one case both isolates carried the HPI, whereas in 11 cases one strain of the pair was HPI-positive. Although there were differences in the organization of the Yersinia HPI, all HPI-positive isolates were able ...

2016
Mais G. Ammari Cathy R. Gresham Fiona M. McCarthy Bindu Nanduri

Identification and analysis of host-pathogen interactions (HPI) is essential to study infectious diseases. However, HPI data are sparse in existing molecular interaction databases, especially for agricultural host-pathogen systems. Therefore, resources that annotate, predict and display the HPI that underpin infectious diseases are critical for developing novel intervention strategies. HPIDB 2....

Journal: :Cloning and stem cells 2009
Fuliang Du Jie Xu Jifeng Zhang Shaorong Gao Mark G Carter Chingli He Li-Ying Sung Sanjeev Chaubal Rafael A Fissore X Cindy Tian Xiangzhong Yang Y Eugene Chen

This study was designed to examine the effect of the age of rabbit oocytes on the developmental potential of cloned embryos. The metaphase II oocytes used for nuclear transfer (NT) were collected at 10, 12, 14, and 16 h post-hCG injection (hpi). The total number of oocytes collected per donor (21.4-23.7) at 12 to 16 hpi was similar, but significantly higher than that collected at 10 hpi (16.2)....

Journal: :PLoS Pathogens 2009
Sören Schubert Pierre Darlu Olivier Clermont Andreas Wieser Giuseppe Magistro Christiane Hoffmann Kirsten Weinert Olivier Tenaillon Ivan Matic Erick Denamur

Horizontal gene transfer is a key step in the evolution of bacterial pathogens. Besides phages and plasmids, pathogenicity islands (PAIs) are subjected to horizontal transfer. The transfer mechanisms of PAIs within a certain bacterial species or between different species are still not well understood. This study is focused on the High-Pathogenicity Island (HPI), which is a PAI widely spread amo...

Journal: :The Journal of biological chemistry 2003
Zhi-Song Qiao Cheng-Yin Min Qing-Xin Hua Michael A Weiss You-Min Feng

Human insulin is a double-chain peptide that is synthesized in vivo as a single-chain human proinsulin (HPI). We have investigated the disulfide-forming pathway of a single-chain porcine insulin precursor (PIP). Here we further studied the folding pathway of HPI in vitro. While the oxidized refolding process of HPI was quenched, four obvious intermediates (namely P1, P2, P3, and P4, respectivel...

Journal: :Journal of clinical microbiology 2001
H Fukushima Y Matsuda R Seki M Tsubokura N Takeda F N Shubin I K Paik X B Zheng

Yersinia pseudotuberculosis produces novel superantigenic toxins designated YPMa (Y. pseudotuberculosis-derived mitogen), YPMb, and YPMc and has a pathogenicity island termed HPI (high-pathogenicity island) and R-HPI (the right-hand part of the HPI with truncation in its left-hand part) on the chromosome. Analysis of the distribution of these virulence factors allowed for differentiation of spe...

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