Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. The purpose of this study was to determine the relationship between estrogen and progesterone receptors with Her-2, Ki67, P53, and clinicopathologica...

background and objective: egfr and her-2 are two members of erbb/her family of type i transmembrane growth factor receptors. cox2 is an enzyme responsible for the conversion of arachidonic acid to prostaglandins, which has a major role in angiogenesis and can modelate tumor growth. the aim of this study was to determine the level of expression of egfr, her-2 and cox2 in colorectd cancer. mater...

background: breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. the purpose of this study was to determine the relationship between estrogen and progesterone receptors with her-2, ki67, p53, and clinicopathologica...

Objectives: MRI is the most sensitive modality for local staging of breast cancer. Herceptin receptor over-expression seen in 15% - 30% tumours, and associated with increased aggression, poorer prognosis, higher grade at diagnosis lymphatic dissemination. This study aimed evaluating role positive vs negative tumours. Methods: 193 pre-operative MRIs were performed 2021 162 Her-2 37 Recall rates ...

Introduction: Overexpression of Human Epidermal Growth factor Receptor-2 (HER-2) is one of the most important prognostic and predictive factors of breast cancer, observed in 25% - 30% of breast carcinoma patients leading to poor prognosis and feasible anti HER-2 antibody drugs. The objective of this study was to evaluate the HER-2 frequency in target population and its correlat...

human epidermal growth factor receptor-2 (her-2) as a new prognostic and predictive factor has been believed as an essential measurement in breast carcinoma. about 280 articles were reviewed and 115 were referred in this review article on her-2. her-2 is an oncoprotein epidermal growth factor receptor produced by a so-called cell surface oncogene. overexpression results in aggressive behavior, ...

Background &Objectives;: Evaluation of estrogen receptor (ER), progesterone receptor (PR), and (human epidermal growth factor receptor-2) Her-2 on core needle biopsies (CNBs) is increasingly in use to diagnosis early breast cancer, but its concordance with surgical excision (SE) is not well documented. Methods: The study ...

background and objectives: breast cancer is the most common malignancy among women in the world. the aim of this study was to assess estrogen receptor (er), progesterone receptor (pr) and her-2/neu of infiltrating ductal carcinoma (idc) with tumor size, histologic grade, lymph node metastasis and age. methods: this study was carried out on 300 tissue blocks ofpatients with idc who underwent mas...

Male breast cancer is a rare disease with an increasing trend. Due to limited information especially about the genetic basis of the disease in Iran and the lower age of its onset, the disease requires more attention. The aim of this study was to screen the male patients with breast cancer for BRCA mutations as well as tissue markers of estrogen receptor (ER), progesterone receptor (PR), human e...