background:breast cancer remains the most common and second lethal cancer in females. her-2/neu is one of the most important amplified oncogene in breast cancer. the amplification of her-2 is correlated with decreased survival, metastasis, and early recurrence.  the amplification of her-2/neu gene and synthesis of the protein are reported in 10%-34% of breast cancer cases associated with tumor ...

A case of 52 years woman with a lump in her right breast. She was evaluated for surgery and modified radical mastectomy (MRM) was done. Grossing of specimen showed two tumors in retro areolar and lower outer quadrant respectively. Histopathology revealed neuroendocrine tumor of the breast. All eighteen lymph nodes showed reactive lymphoid hyperplasia. Immunohistochemical report showed cells wer...

BACKGROUND The aim of the research was to estimate the frequency of the locoregional breast cancer recurrence appearance, the recurrence-free period continuance, and the 3- and 5-year survival depending on the scope of the surgical intervention, menstrual profile, and histological and molecular-biologic characteristics of the primary tumor. PATIENTS AND METHODS Among 218 patients with a breas...

Invasive lobular carcinoma is a distinct biological entity with several histologic variants the prognostic value of which is not fully elucidated. The aim of this study was to determine the immunohistochemical expression of estrogen receptors (ER) and progedterone receptors (PR) in subtypes of lobular breast carcinoma (classic and variant types) and to correlate them with clinical and tumor par...

Previous studies have suggested that overexpression of HER-2/neu oncogene occurs in 15-40% of breast cancers and that overexpression is associated with poor prognosis. In the present report, we have used an immunohistochemical technique involving a monoclonal antibody specifically reactive with the external domain of HER-2/neu to study expression of HER-2/neu in frozen sections of normal ovary ...

Background: Breast cancer is a systemic disease which has different biological subtypes with vast natural history, clinical presentation, various pathological types and molecular features impact on prognostic profile outcome. Present study aims to evaluate correlation of receptor status (ER, PR HER 2neu) other tumor characteristics.Methods: The present was prospective observational 50 breast pa...