نتایج جستجو برای: HCA

تعداد نتایج: 1383  

Journal: :Journal of Biomolecular Screening 2010

2013
S. Fonseca D. Hoton S. Dardenne L. Annet C. Hubert S. Godecharles A. Jouret-Mourin R. Reding J. B. Otte J. Rahier J. F. Gigot C. Sempoux

Light has been shed on the genotype/phenotype correlation in hepatocellular adenoma (HCA) recognizing HNF1 α -inactivated HCA (H-HCA), inflammatory HCA (IHCA), and β -catenin-activated HCA (b-HCA). We reviewed retrospectively our surgical HCA series to learn how to recognize the different subtypes histopathologically and how to interpret adequately their immunohistochemical staining. From Janua...

2013
Hyun Hee Chu Woo Sung Moon

Hepatocellular adenoma (HCA) is a benign liver tumor composed of hepatocytes. HCA represents a heterogeneous entity, and is subclassified into four groups according to genotype and phenotype: hepatocyte nuclear factor (HNF) 1α-inactivated HCA, β-catenin-activated HCA, inflammatory HCA, and unclassified HCA. Theses subtypes vary greatly in their clinical and pathological features. Identifying th...

Journal: :Diagnostic pathology 2016
Elizabeth Margolskee Fei Bao Anne Koehne de Gonzalez Roger K Moreira Stephen Lagana Anthony N Sireci Antonia R Sepulveda Helen Remotti Jay H Lefkowitch Marcela Salomao

BACKGROUND Four subtypes of hepatocellular adenomas (HCA) are recognized: hepatocyte-nuclear-factor-1α mutated (H-HCA), β-catenin-mutated type with upregulation of glutamine synthetase (b-HCA), inflammatory type (IHCA) with serum-amyloid-A overexpression, and unclassified type. Subtyping may be useful since b-HCA appear to have higher risk of malignant transformation. We sought to apply subtype...

Journal: :Digestive surgery 2010
Paulette Bioulac-Sage Charles Balabaud Jessica Zucman-Rossi

Hepatocellular adenomas (HCA) are rare benign tumours occurring mainly in women under oral contraceptives. HCA bleed frequently and transform rarely into hepatocellular carcinoma. Identification of genes recurrently mutated in HCA and good genotype/phenotype correlations provided the basis of a pathomolecular classification of different HCA subgroups, characterized using immunohistochemical mar...

2011
Kashan Ahmed

In the recent past, deorphanization studies have described intermediates of energy metabolism to activate G protein-coupled receptors and to thereby regulate metabolic functions. GPR81, GPR109A, and GPR109B, formerly known as the nicotinic acid receptor family, are encoded by clustered genes and share a high degree of sequence homology. Recently, hydroxy-carboxylic acids were identified as endo...

Journal: :Bioscience, biotechnology, and biochemistry 2005
Hiroyuki Hida Takashi Yamada Yasuhiro Yamada

Hydroxycitric acid (HCA) is a major acid component of the tropical plants Garcinia cambogia and Hibiscus subdariffa. (2S,3S)-HCA from G. cambogia was shown to be a potent inhibitor of ATP citrate lyase (EC4.1.3.8), which catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA. (2S,3R)-HCA from H. subdariffa inhibits alpha-amylase and alpha-glucosidase, leading to red...

2014
Hilal Kuday Fatih Sonmez Cigdem Bilen Emre Yavuz Nahit Gençer Mustafa Kucukislamoglu

In vitro inhibition effects of indolylchalcones and new pyrido[2,3-d]pyrimidine derivatives on purified human carbonic anhydrase I and II (hCA I and II) were investigated by using CO2 as a substrate. The results showed that all compounds inhibited the hCA I and hCA II enzyme activities. Among all the synthesized compounds, 7e (IC50 = 6.79 µM) was found to be the most active compound for hCA I i...

2016
Shuqing Liu Chunmei Guo Jiasheng Wang Bo Wang Houbao Qi Ming-Zhong Sun

Annexin A11 (Anxa11) is associated with various cancers. Using a pair of syngeneic murine hepatocarcinoma cells, Hca-P with ~25% and Hca-F with ~75% lymph node metastatic (LNM) potentials, we demonstrated Anxa11 involvement in hepatocarcinoma lymphatic metastasis. Here, ANXA11 acted as a suppressor for the tumorigenicity, LNM and 5-FU resistance of Hca-P via c-Jun. We constructed monoclonal Hca...

2013
Paulette Bioulac-Sage Christine Sempoux Laurent Possenti Nora Frulio Hervé Laumonier Christophe Laurent Laurence Chiche Jean Frédéric Blanc Jean Saric Hervé Trillaud Brigitte Le Bail Charles Balabaud

In Europe and North America, hepatocellular adenomas (HCA) occur, classically, in middle-aged woman taking oral contraceptives. Twenty percent of women, however, are not exposed to oral contraceptives; HCA can more rarely occur in men, children, and women over 65 years. HCA have been observed in many pathological conditions such as glycogenosis, familial adenomatous polyposis, MODY3, after male...

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