background: hepatitis b virus (hbv) gene and protein variations are frequently been seen in chronic patients. the aims of study were to determine the genotypes as well as the patterns of variations distribution in chronically-infected patients from the central part of iran. methods: the surface gene was amplified, sequenced and subsequently aligned using international and national iranian datab...

objective(s) the aim of this study was to characterize the hepatitis b virus surface protein genotypes and sequence variations among hepatitis b virus surface antigen (hbsag) positive chronic patients in hormozgan province, south of iran. materials and methods a total of 8 patients enrolled in this study. the surface gene was amplified and directly sequenced. genotypes and nucleotide/amino acid...

To determine the prevalence of viral hepatitis infection and hepatitis B virus (HBV) molecular characterization, 11,200 blood donors from citizens of Shahrekord (a city located in west of Iran) were investigated. Results showed HBsAg-positive in 1.78% of persons (n=200), anti-HDV-positive in 3% of HBsAg-positive cases (n=6) and anti-HCV-positive in 0.67% of donors (n=76). HBV phylogenetic analy...

High incidence of HCC is mostly due to the combination of two major risk factors, chronic infection with hepatitis B (HBV) and/or C (HCV) viruses and exposure to the mycotoxin aflatoxin B(1), which induces a particular mutation at codon 249 in TP53 (R249S). Eight genotypes of HBV are diversely found in high and low incidence areas. Regardless of documented strong associations between TP53 R249S...

Hepatitis B virus (HBV) infection is a public health problem as a cause of liver diseases including hepatocellular carcinoma and cirrhosis. It is estimated that 350 million people live with chronic infection and about one million people die every year from complication of this chronic disease in the world. So far, ten HBV genotypes (A-J) has been identified which show a geographical distributio...

Objective(s) The aim of this study was to characterize the hepatitis B virus surface protein genotypes and sequence variations among hepatitis B virus surface antigen (HBsAg) positive chronic patients in Hormozgan province, south of Iran. Materials and Methods A total of 8 patients enrolled in this study. The surface gene was amplified and directly sequenced. Genotypes and nucleotide/amino a...

BACKGROUND Hepatitis B virus (HBV) has been classified into ten genotypes (A-J) based on genome sequence divergence, which is very important for etiological and clinical investigations. HBV genotypes have distinct geographical distributions worldwide. OBJECTIVES The aim of this study was to investigate the distribution of HBV genotypes among Azerbaijani patients with chronic hepatitis B, came...

abstract background: naturally occurred hepatitis b virus (hbv) with surface mutations in a variety of chronic hepatitis b (chb) patients who have received no vaccine or hbig bearing substitutions in surface protein, have been reported. objectives: current knowledge concerning the prevalence of these naturally occurring surface antigen mutations among iranian carriers is limited. patients and m...

BACKGROUND The aim of this study was to investigate, for the first time, the genotype of hepatitis B virus (HBV) among hepatitis patients in Eastern Azerbaijan Province, Northwest Iran. METHODS A total of 100 HBV-infected patients were enrolled in this study. Among these, 40 samples were positive for both HBsAg and HBeAg, whereas 60 samples were HBsAg positive and HBe Agnegative. Patients' se...

background and aims: the aim of this study was to determine the correlation between the hepatitis b virus surface ag (hbsag) genotypes and variations in the clinical/serological pictures among hbsag positive chronic patients from south khorasan province of iran. methods: twenty-five patients were enrolled in this study. the hbs ag gene was amplified and was directly sequenced. genotypes and nuc...