نتایج جستجو برای: Guanylyl cyclase

تعداد نتایج: 17414  

Journal: :The Journal of biological chemistry 1996
H Kuwayama P J Van Haastert

Chemoattractants transiently activate guanylyl cyclase in Dictyostelium discoideum cells. Mutant analysis demonstrates that the produced cGMP plays an essential role in chemotactic signal transduction, controlling the actomyosin-dependent motive force. Guanylyl cyclase activity is associated with the particulate fraction of a cell homogenate. The addition of the cytosol stimulates guanylyl cycl...

Journal: :The Journal of biological chemistry 1999
A Schrem C Lange M Beyermann K W Koch

The membrane-bound guanylyl cyclase in rod photoreceptors is activated by guanylyl cyclase-activating protein 1 (GCAP-1) at low free [Ca2+]. GCAP-1 is a Ca2+-binding protein and belongs to the superfamily of EF-hand proteins. We created an oligopeptide library of overlapping peptides that encompass the entire amino acid sequence of GCAP-1. Peptides were used in competitive screening assays to i...

Journal: :Human pathology 2010
Brody Winn Rosemarie Tavares Andres Matoso Lelia Noble Jacqueline Fanion Scott A Waldman Murray B Resnick

Guanylyl cyclase C, a receptor for bacterial diarrheagenic enterotoxins, is expressed selectively by intestinal epithelium and is an endogenous downstream target of CDX2. The expression of Guanylyl cyclase C is preserved throughout the adenoma/carcinoma sequence in the colorectum. Detection of Guanylyl cyclase C expression by reverse transcriptase-polymerase chain reaction is currently being va...

Journal: :The Journal of biological chemistry 2009
Sayanti Saha Kabir Hassan Biswas Chandana Kondapalli Nishitha Isloor Sandhya S Visweswariah

Receptor guanylyl cyclases are multidomain proteins, and ligand binding to the extracellular domain increases the levels of intracellular cGMP. The intracellular domain of these receptors is composed of a kinase homology domain (KHD), a linker of approximately 70 amino acids, followed by the C-terminal guanylyl cyclase domain. Mechanisms by which these receptors are allosterically regulated by ...

Journal: :international journal of molecular and cellular medicine 0
pouria mohammadi research center for molecular medicine, hamadan university of medical sciences, hamadan, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (hamadan university of medical sciences) massoud saidijam research center for molecular medicine, hamadan university of medical sciences, hamadan, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (hamadan university of medical sciences) arastoo kaki research center for molecular medicine, hamadan university of medical sciences, hamadan, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (hamadan university of medical sciences) katayoon etemadi research center for molecular medicine, hamadan university of medical sciences, hamadan, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (hamadan university of medical sciences) nooshin shabab research center for molecular medicine, hamadan university of medical sciences, hamadan, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (hamadan university of medical sciences) reza yadegarazari research center for molecular medicine, hamadan university of medical sciences, hamadan, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (hamadan university of medical sciences)

colorectal cancer remains one of the major cancer- related deaths despite progress in the treatment during past decades. detection of disease at earlier stages reduces its mortality. the aim of current study was to investigate expression of cytokeratin 19 (ck19), cytokeratin 20 (ck20) and guanylyl cyclase c (gcc) mrna in peripheral blood of non- metastatic colorectal cancer patients which may r...

Journal: :Hypertension 1997
L J Olson E T Knych T C Herzig J G Drewett

Effects of a novel soluble guanylyl cyclase inhibitor, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), were characterized on guanylyl cyclase activity in cytosolic fraction of COS-7 cells overexpressing the alpha 1 and beta 1 subunits of the rat soluble enzyme. ODQ was a noncompetitive inhibitor of soluble guanylyl cyclase with respect to Mn2+ or Mn(2+)-GTP and was a mixed competitive/noncom...

Journal: :The Journal of pharmacology and experimental therapeutics 2005
Shiva Kazerounian Giovanni M Pitari Fawad J Shah Glen S Frick Muniswamy Madesh Inez Ruiz-Stewart Stephanie Schulz Gyorgy Hajnóczky Scott A Waldman

Guanylyl cyclase C and accumulation of cGMP induced by bacterial heat-stable enterotoxins (STs) promote colon cancer cell cytostasis, serving as a tumor suppressor in intestine. Conversely, capacitative calcium entry through store-operated calcium channels (SOCs) is a key signaling mechanism that promotes colon cancer cell proliferation. The present study revealed that proliferative signaling b...

Journal: :The EMBO journal 1997
H Ma M Gamper C Parent R A Firtel

We have identified a MAP kinase kinase (DdMEK1) that is required for proper aggregation in Dictyostelium. Null mutations produce extremely small aggregate sizes, resulting in the formation of slugs and terminal fruiting bodies that are significantly smaller than those of wild-type cells. Time-lapse video microscopy and in vitro assays indicate that the cells are able to produce cAMP waves that ...

Journal: :The Journal of biological chemistry 1991
Y Horio F Murad

Guanylyl cyclase from bovine rod outer segments was solubilized using Triton X-100 and a high concentration of KCl, and its regulation was studied. The efficiency of solubilization was about 50-90% of total activity. When the Ca2+ content was lowered (less than 80 nM), guanylyl cyclase was activated about 2-fold. In the presence of higher concentrations of Ca2+ (greater than 140 nM), the activi...

Journal: :Frontiers in bioscience : a journal and virtual library 2005
Pauline Schaap

This review explores the origins, diversity and functions of guanylyl cyclases in cellular organisms. In eukaryotes both cGMP and cAMP are produced by the conserved class III cyclase domains, while prokaryotes use five more unrelated catalysts for cyclic nucleotide synthesis. The class III domain is found embedded in proteins with a large variety of membrane topologies and other functional doma...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید