the present study aimed at investigating the beneficial effects of co-administering granulocyte colony–stimulating factor (g-csf) and stem cell factor (scf) in a model of chronic liver injury induced by thioacetamide (taa). biochemical and histopathology- cal examinations were performed on serum and liver specimens. at the end of the treatment period, the rats were anesthetized with ether, seru...

introduction: this study was designed to investigate the effects of granulocyte colony-stimulating factor (g-csf) administration in rats for 6 weeks after traumatic brain injury (tbi). methods: adult male wistar rats (n = 30) were injured with controlled cortical impact device and divided into four groups. the treatment groups (n = 10 each) were injected subcutaneously with recombinant human g-...

the cytokine of granulocyte macrophage colony stimulating factor (gm-csf) is a glycoprotein, which is synthesized in the female reproductive tract and has embryonic trophic effect in mammals. the objective of this study was to examine the optimal dosage of gm-csf to improve the mouse embryo development in vitro. to collect two and eight cells embryos, the pregnant nmri mice were sacrificed by c...

background: stroke is the third leading cause of death. hypothermia has been recognized as an effective method in reducing brain injury. in this study, we assessed the effects of granulocyte colony-stimulating factor (g-csf) as a neuroprotective agent and mild hypothermia on mortality, behavioral function, infarct volume, and brain edema in wistar rats. methods: forty male rats were used in fiv...

traumatic brain injury (tbi) is described as a situation in which the brain is damaged by an external force. it is considered to be a chief problem in health care. pharmacotherapy and stem cell therapy are the main treatments used in tbi. the purpose of these procedures is to control the inflammation in injured regions of brain. currently, there is no effective care for tbi that could regenerat...

human granulocyte colony stimulating factor (hg-csf) induces proliferation and differentiation of granulocyte progenitor cells. this glycoprotein is currently being used for treatment of neutropenia, in patients who have undergone bone marrow transplantation. so far, different researchers have tried to enhance hg-csf biological activity and stability. in this study, polymerase chain reaction (p...

background: recently, the use of granulocyte colony-stimulating factor (g-csf) has been proposed to improve pregnancy outcomes in reproductive medicine. objective: a systematic review of the current use of g-csf in patients who have difficulty conceiving and maintaining pregnancy was performed. materials and methods: two electronic databases (pubmed/ medline and scopus) were searched. study sel...

background: the protein hormone granulocyte colony-stimulating factor (gcsf) stimulates the production of white blood cells and plays an important role in medical treatment of cancer patients. methods: an efficient process was developed for heterologous expression of human gcsf in e. coli bl21 (de3). the feeding rate was adjusted to achieve the maximum attainable specific growth rate under crit...

background: granulocyte colony stimulating factors (gcsf) are high cost agents commonly recommended for primary and secondary prophylaxis of chemotherapy-induced neutropenia and febrile neutropenia. gcsfs have been shown to be beneficial in some patient subgroups, although they are probably overused in clinical settings. the american society of clinical oncology (asco) guidelines summarize curr...