experimental work was carried out to investigate the influence of impeller speed, granulation time, binder mass and their interactions on granule size distribution, mean size and binder content distribution in a conical high shear granulator. it was observed that the response of high shear granulation to changes in process parameters varies significantly from one operating condition to another....

Experimental work was carried out to investigate the influence of impeller speed, granulation time, binder mass and their interactions on granule size distribution, mean size and binder content distribution in a conical high shear granulator. It was observed that the response of high shear granulation to changes in process parameters varies significantly from one operating condition to anot...

Understanding the relationship between processing parameters of fluidized bed wet granulation and the characteristics of intermediate and final products is crucial in the pharmaceutical processes. This research examined a fluidized bed wet granulation process containing a cornstarch solution as binder and lactose particles as powder. The design of experiment (DoE) was performed according to an ...

The effect of some drug properties (wettability and particle size distribution) on granule properties (mean particle size, particle size distribution, sphericity, and granule strength) were investigated in a high (>97%) drug-loading formulation using fluidized bed rotor granulation. Three drugs: acetaminophen (APAP); ibuprofen (IBU); and ethenzamide (ETZ) were used as model drugs based on their...

"Specific granule" deficiency (SGD) has been previously associated with lactoferrin deficiency. The antimicrobial peptides termed defensins, comprising 30% of normal primary granule proteins, have also been shown to be markedly deficient in SGD. The present study was undertaken to correlate these findings with ultrastructural morphometric analysis and peroxidase cytochemistry. Peroxidase-positi...

Temporal lobe epilepsy is common and difficult to treat. Reduced inhibition of dentate granule cells may contribute. Basket cells are important inhibitors of granule cells. Excitatory synaptic input to basket cells and unitary IPSCs (uIPSCs) from basket cells to granule cells were evaluated in hippocampal slices from a rat model of temporal lobe epilepsy. Basket cells were identified by electro...

dissolution pressure and nozzle temperature effects on particle size and distribution were investigated for ress (rapid expansion of supercritical solution) process. supercritical co2 was used as solvent and ibuprofen was applied as the model component in all runs. the resulting ibuprofen nano-particles (about 50 nm in optimized runs) were analyzed by sem and laser diffraction particle size ana...

Multiple regression analysis (MRA) and principal component analysis (PCA) have been used in the present study to examine the relationships between the operational conditions of a unique multi-functional rotor processor, material attributes such as water content during granulation, and a series of associated micromeritics, including the flowability, granule mean size and granule density values. ...